Opportunistic protozoa Pathogens Disease Sites parasitized Toxoplasma gondi toxoplasmosis All cells except rBC Cryptosporidium spp. cryptosporidiosis Intestinal epithelium Isospora spp. isosporiasIs Intestinal epithelium microsporidia micros porIdIOSIS Intestinal epithelium Brain, liver, kidney.. Blastocystis hominis blastocystosis intestine Pneumocystis jeroveci Pneumocystis lung (Pneumocystis carinii)pneumonia(PCP
Opportunistic protozoa Pathogens Disease Sites parasitized Toxoplasma gondii toxoplasmosis All cells except RBC Cryptosporidiumspp. cryptosporidiosis Intestinal epithelium Isospora spp. isosporiasis Intestinal epithelium microsporidia microsporidiosis Intestinal epithelium Brain, liver, kidney… Blastocystis hominus blastocystosis intestine Pneumocystisjeroveci (Pneumocystis carinii) Pneumocystis pneumonia (PCP) lung
ToXoplasma gondi (toxoplasmosis
Toxoplasma gondii (toxoplasmosis)
Introduction ToXoplasma gondii has very low host specificity, and it will probably infect almost any mammal. It invades all kinds of cells except RBC Cats (both domestic and wild) are the only definitive hosts and can also be the intermediate hosts The disease that ToXoplasma gondii caused (toxoplasmosis) has been found in virtually every country of the world Toxoplasmosis is a significant cause of morbidity and mortality in AIDS patients and congenitally infected infants--opportunistic infection for human
• Toxoplasma gondii has very low host specificity, and it will probably infect almost any mammal. It invades all kinds of cells except RBC • Cats (both domestic and wild) are the only definitive hosts and can also be the intermediate hosts • The disease that Toxoplasma gondii caused (toxoplasmosis) has been found in virtually every country of the world • Toxoplasmosis is a significant cause of morbidity and mortality in AIDS patients and congenitally infected infants -- opportunistic infection for human Introduction
Morphology Trophozoite The intracellular parasites( tachyzoite速殖子)are 3X6um, crescent shaped organisms that are enclosed in a cell membrane to form a pseudocyst(假包囊) measuring 10-100 um in size Toxoplasma gondii tachyzoites (by P.w. Pappas and S.M. Wardrop)
Morphology • Trophozoite – The intracellular parasites (tachyzoite速殖子) are 3x6µm, crescent shaped organisms that are enclosed in a cell membrane to form a pseudocyst (假包囊) measuring 10-100 µm in size
Morphology Pseudocyst intracellular tachyzoites of ToXoplasma gondii
Morphology • Pseudocyst -- intracellular tachyzoites of Toxoplasma gondii