Immunologic mechanisms of renal di seases Chen weilin, Ph.d o6 Institute of Immunology ZJU Email:cWl@zju.edu.cn
Immunologic mechanisms of renal diseases Chen weilin，PH.D Institute of Immunology, ZJU Email：cwl@zju.edu.cn
Antigens The cause of immunologically mediated renal disease is antigenic triggering of an immune reaction The list of associated antigens is extensive and continually expanding. These antigens are categorized as renal or non-renal and as self or foreign The causative antigen is often unknown
• The cause of immunologically mediated renal disease is antigenic triggering of an immune reaction. • The list of associated antigens is extensive and continually expanding. These antigens are categorized as renal or non-renal and as self or foreign . • The causative antigen is often unknown. Antigens
ANTIGENS ASSOCIATED WITH IMMUNOLOGICALLY MEDIATED RENAL DISEASE Renal Self (endogenous) Glomerular basement membrane (particularly type Iv collagen) Tubular basement membrane Foreign (exogenous) Transplantation antigens (HLA) Nonrenal Self (endogenous) Nucleic acids PMN cVtoplasmic antigens Tumor antigens Cryoglobulins Foreign (exogenous) Bacteria (eg. B-hermolytic strepto coccus) iruses (eg, HIV) Allergens (eg bee sting, pollen. vaccines Drugs (eg. methicillin)
ANTIGENS ASSOCIATED WITH IMMUNOLOGICALLY MEDIATED RENAL DISEASE
Antigens To cause immunologically mediated renal disease, an antigen must localize to the kidney and trigger a local immune inflammatory response. Renal antigens are inherently localized, being constituent proteins of the kidney Non-renal antigens require a mechanism for depositing in the kidney
Antigens • To cause immunologically mediated renal disease, an antigen must localize to the kidney and trigger a local immune inflammatory response. • Renal antigens are inherently localized, being constituent proteins of the kidney. • Non-renal antigens require a mechanism for depositing in the kidney
Immunologic mechanisms of renal diseases Type ll hypersensitivity (Cytotoxic Antibody-mediated Type Ill hypersensitivity (Immune Complex-mediated Cell-mediated immunity (CD4+ CD8+ T) Abnormal Immune regulation(Ts) Immune hereditary factors (HLA)
Immunologic mechanisms of renal diseases • Type II hypersensitivity (Cytotoxic Antibody-mediated ) • Type III hypersensitivity (Immune Complex-mediated ) • Cell-mediated immunity (CD4+ ,CD8+ T) • Abnormal Immune regulation(Ts) • Immune hereditary factors(HLA)