b.PharmacodynamicsofBenzodiazepines&Barbituratesi.MolecularPharmacologyoftheGABAAReceptoriiNeuropharmacologyii.OrganLevelEffectsc.Tolerance:Psychologic &Physiologic Dependenceiv,BENZODIAZEPINEANTAGONISTS:FLUMAZENILV.NEWERDRUGSFORANXIETY&SLEEPDISORDERSvi.CLINICALPHARMACOLOGYOFSEDATIVE-HYPNOTICSTREATMENTOFANXIETYSTATESviiTREATMENTOFSLEEPPROBLEMSPharmacologic Management ofParkinsonism andOther MovementDisorders4Total hours required -2Total Classes required -Days of Study =Mon, Tue, Wed, Thu, Fri, Mon, Tue,WedTest=ThursdayPeriod of Study=Weekl&2-Firstsemestera. Lecture 1 Class XVIIIiEtiology of Parkinsonismii.TherapymethodofParkinsonisma.Increasesbraindopaminelevelslevodopab,Dopamineagonists,directlystimulateDAreceptorsc.Monoamineoxidase(MAO)inhibitors,preventdopaminemetabolismd.Anticholinergic agentsii.Pharmacokinetics of levodopaiv. Clinical Usev.AdverseEffectb.Lecture 2 Class XIXiDrugInteractionsa.Vitamin pyridoxine(B6)b.MAO inhibitors (phenelzine)c.In patients with glaucomad.Antipsychotic drugii.Contraindications
b. Pharmacodynamics of Benzodiazepines & Barbiturates i. Molecular Pharmacology of the GABAA Receptor ii. Neuropharmacology iii. Organ Level Effects c. Tolerance: Psychologic & Physiologic Dependence iv. BENZODIAZEPINE ANTAGONISTS: FLUMAZENIL v. NEWER DRUGS FOR ANXIETY & SLEEP DISORDERS vi. CLINICAL PHARMACOLOGY OF SEDATIVEHYPNOTICS TREATMENT OF ANXIETY STATES vii. TREATMENT OF SLEEP PROBLEMS Pharmacologic Management of Parkinsonism and Other Movement Disorders Total hours required = 4 Total Classes required = 2 Days of Study = Mon, Tue, Wed, Thu, Fri, Mon, Tue, Wed Test= Thursday Period of Study = Week 1&2 –First semester a. Lecture 1 Class XVIII i. Etiology of Parkinsonism ii. Therapy method of Parkinsonism a. Increases brain dopamine levels levodopa b. Dopamine agonists, directly stimulate DA receptors c. Monoamine oxidase (MAO) inhibitors, prevent dopamine metabolism d. Anticholinergic agents iii. Pharmacokinetics of levodopa iv. Clinical Use v. Adverse Effect b. Lecture 2 Class XIX i. Drug Interactions a.Vitamin pyridoxine(B6) b. MAO inhibitors (phenelzine) c. In patients with glaucoma d. Antipsychotic drug ii. Contraindications
ili. Specific agentsa.DopamineAgonists:Bromocriptineb.Monoamine oxidase inhibitors:rasagilinec.Catechol-O-Methyl Transferase Inhibitors :tolcaponeand entacaponed. Anticholinergic Drugsopioid analgesics and antagonist opioid analgesics and antagonist2Total hours required =1Total Classes required =Daysof Study=Mon, Tue, Wed, Thu,Fri, Mon, Tue,WedTest=ThursdayPeriod of Study =Week 1&2-First semesterLecture 1 Class XXi The classification ofthe painii. Classification of the opioid analgesicsili.Mechanismofactioniv.ToleranceandPhysicalDependencev.Organ system effectsofmorphineand its surrogatesa.Central nervous system effectsb.Peripheral effectsvi.Clinical use of opioid analgesicsvii.Toxicity and adverse reaction of opioid analgesicsvili.Diagnosis and treatment of opioid overdosageix,Contraindication and cautions intherapya. Use of pure agonists with weak partial agonistsb.Use in patientswith head injuriesc.Use during pregnancyd.Useinpatients with impaired pulmonaryfunctione.Use in patientswith impaired hepatic orrenal Functionf.Useinpatientswithendocrinediseasex.Specific agents,Meperidinexi. The opiod antagonistAntipsychotic Drugs4Total hours required =-2Total Classes required =-
iii. Specific agents a. Dopamine Agonists : Bromocriptine b. Monoamine oxidase inhibitors: rasagiline c. Catechol-O-Methyl Transferase Inhibitors :tolcapone and entacapone d. Anticholinergic Drugs opioid analgesics and antagonist opioid analgesics and antagonist Total hours required = 2 Total Classes required = 1 Days of Study = Mon, Tue, Wed, Thu, Fri, Mon, Tue, Wed Test= Thursday Period of Study = Week 1&2 –First semester Lecture 1 Class XX i. The classification of the pain ii. Classification of the opioid analgesics iii. Mechanism of action iv. Tolerance and Physical Dependence v. Organ system effects of morphine and its surrogates a. Central nervous system effects b. Peripheral effects vi. Clinical use of opioid analgesics vii.Toxicity and adverse reaction of opioid analgesics viii. Diagnosis and treatment of opioid overdosage ix. Contraindication and cautions in therapy a. Use of pure agonists with weak partial agonists b. Use in patients with head injuries c. Use during pregnancy d. Use in patients with impaired pulmonary function e. Use in patients with impaired hepatic or renal Function f. Use in patients with endocrine disease x. Specific agents, Meperidine xi. The opiod antagonist Antipsychotic Drugs Total hours required = 4 Total Classes required = 2