IntegrinactivationMigration throughRollingStableadhesionbychemokinesendotheliumLeukocyteSialyl-LewisX-modifiedglycoproteinIntegrin(lowaffinitystate)Integrin(highaffinity state)PECAM-1(CD31)P-selectin E-selectinIntegrinligand(ICAM-1)ProteoglycanChemokinesCytokinesMacrophage(TNF,IL-1)withmicrobesFibrinandfibronectin(extracellularmatrixThe multipleprocessofleukocyte migrationthroughbloodvesselsRobbins andCotranPathologicBasis ofDisease7thedition
The multiple process of leukocyte migration through blood vessels Robbins and Cotran Pathologic Basis of Disease 7th edition
lumen of capilaryselectinendothelial cellRreceptorfor TNFandinterleukin1(cytokines)
Leukocyte margination and rolling
Leukocyte margination and rolling
Leukocyte marginationand rolling
Leukocyte margination and rolling
LeucocytestransmigrationandchemotaxisWBC通过血管壁进入周围组织的过程称游出（transmigration）阿米巴运动（ameboidmovement)过程：WBC（中性粒细胞，嗜酸性粒细胞，嗜碱性粒细胞，单核细胞，淋巴细胞）粘附于内皮细胞一在内皮细胞连接处伸出伪足，以阿来巴运动的方式从内皮细胞之间挤出一穿过基底膜（分泌胶原酶，降解血管基底膜）一内皮细胞连接结构恢复正常（2-12min）速度：中性粒细胞>单核细胞>淋巴细胞>嗜酸性粒细胞>嗜碱性粒细胞（主动游出）
Leucocytes transmigration and chemotaxis WBC通过血管壁进入周围组织的过程称游出(transmigration) 阿米巴运动 (ameboid movement) 过程：WBC（中性粒细胞，嗜酸性粒细胞，嗜碱性粒细胞， 单核细胞，淋巴细胞）粘附于内皮细胞→在内皮细胞连接处 伸出伪足，以阿米巴运动的方式从内皮细胞之间挤出→穿过 基底膜（分泌胶原酶，降解血管基底膜）→内皮细胞连接结 构恢复正常（2-12min） 速度：中性粒细胞＞单核细胞＞淋巴细胞＞嗜酸性粒细胞＞ 嗜碱性粒细胞（主动游出）