Watson、 Crick的DNA双螺旋结构
呆爱的沃置,汉萨幼雅 1953年的某一天,沃森和克里克看出来对那由X光所产生的图 案的最佳解释:DNA具有双螺旋的形状—个有点像螺旋的构造 体。突然之间,一切都变得很清楚
Nature 171, 737-734(1953)(C)Macmillan Publishers Ltd Molecular structure of nucleic acids WatSON..d. CRiCKfh c Medical research Council Unit for the study of Molecular Structure of Biological Systems, Cavendish Laboratory, Cambridge A Structure for Deoxyribose This figure is purely Nucleic Acid diagrammatic The two ribbons We wish to suggest a structure for symbolize the the salt of deoxyribose nucleic acid two phophate sugar chains, and (D.N.A.). This structure has novel the horizonal features which are of considerable rods the pairs of bases holding the biological interest chains together The vertical line marks the fibre axIs
Nature 171, 737-734 (1953) (C) Macmillan Publishers Ltd. Molecular structure of Nucleic Acids WATSON, J. D. & CRICK, F. H. C. Medical Research Council Unit for the Study of Molecular Structure of Biological Systems, Cavendish Laboratory, Cambridge. A Structure for Deoxyribose Nucleic Acid We wish to suggest a structure for the salt of deoxyribose nucleic acid (D.N.A.). This structure has novel features which are of considerable biological interest. Figure 1 This figure is purely diagrammatic. The two ribbons symbolize the two phophate- sugar chains, and the horizonal rods the pairs of bases holding the chains together. The vertical line marks the fibre axis
历史回顾 70年代初,DNA已可在体外被随意拼接并 转回到细菌体内遗传和表达
l 70年代初，DNA已可在体外被随意拼接并 转回到细菌体内遗传和表达 一 、历史回顾
历史回顾 今天,人们在超市货价上可以买到保质期很长 的转基因土豆,“多利”克隆绵羊走进实验室,基 因工程正在使整个人类生活方式发生重大变革。 20006.26宣告人类基因组“工作框架图”绘制 毕 目前还有许多有价值的微生物,动物,植物的 测序工作正在进行中。 http://www.nature.com/geno
l 今天，人们在超市货价上可以买到保质期很长 的转基因土豆， “多利”克隆绵羊走进实验室，基 因工程正在使整个人类生活方式发生重大变革。 l 2000.6.26宣告人类基因组“工作框架图”绘制 完毕。 l 目前还有许多有价值的微生物，动物，植物的 测序工作正在进行中。 http://www.nature.com/genomics/ 历史回顾