第六章 Regulation of transcription in eukaryotes 构成性转录因子SP1对持家基因的调控作用 1、 Housekeeping( constitutive) genes(持家 基因):细胞内的蛋白质编码基因,维持细胞的基 本过程。 2、SP1结合于保守性序列 GGGCGG的GC丰富 序列,该序列位于许多持家基因的启动子中。 3、SP含有:3 zinc finger motifs which bind to GC-rich sequance, 2 glutamine-rich domains interact with TAFu110 of TFII D
第六章 Regulation of transcription in eukaryotes 一、构成性转录因子SP1对持家基因的调控作用 1、Housekeeping （constitutive）genes （持家 基因） : 细胞内的蛋白质编码基因，维持细胞的基 本过程。 2、 SP1结合于保守性序列GGGCGG的GC丰富 序列，该序列位于许多持家基因的启动子中。 3、 SP1含有: 3 zinc finger motifs which bind to GC-rich sequance , 2个 glutamine-rich domains interact with TAFII110 of TFII D
The specific transcription factor sPl binds to GC rich sequence in TATA less promoter glutamine-rich domains 110 zinc finger motifs SRi TBP GC
GC SP1SP1 TBP 110 TBP The specific transcription factor SP1binds to GC rich sequence in TATA less promoter glutamine-rich domains zinc finger motifs
二、 Hormone regulation: Hormones are molecules which are secreted by one specific cell type and transmit a signal to a target cell type
二、Hormone regulation: Hormones are molecules which are secreted by one specific cell type and transmit a signal to a target cell type
(1 Steroid hormone and their receptors 1 Steroid hormones, lipid soluble and can diffuse through cell membranes to interact with transcription factor, steroid hormone receptors 2、 Steroid hormones glucocorticoid糖皮质激素 estrogen雌激素 retinoic acid视黄酸 thyroid甲状腺素
（1）、Steroid hormone and their receptors 1、 Steroid hormones, lipid soluble and can diffuse through cell membranes to interact with transcription factor, steroid hormone receptors. 2、 Steroid hormones： glucocorticoid 糖皮质激素 estrogen 雌激素 retinoic acid 视黄酸 thyroid 甲状腺素
3 General steroid model of gene transcription activation inhibitor Glucocorticoid receptor uclear translocation GREI
3、General steroid model of gene transcription activation Glucocorticoid GRE receptor inhibitor Nuclear translocation