4.1Typical Clinical features Sed limey hae Acute nephritic syndrome The most frequent presentation >edema hematuria hypertension >with or without oliguria ◆A pproximately 95% of clinical cases have at least 2 manifestations +40%o have the full-blown acute nephritic syndrome
4.1 Typical Clinical features ---- Acute nephritic syndrome ♦ The most frequent presentation ➢edema ➢ hematuria ➢hypertension ➢with or without oliguria. ♦ Approximately 95% of clinical cases have at least 2 manifestations ♦ 40% have the full-blown acute nephritic syndrome
Typical Clinical featureswue (ta Sand ilin, physi R -- Preceding streptococcal infection Tonsillitis otitis media cervical adenitis impetigo
Typical Clinical features --- Preceding streptococcal infection impetigo Tonsillitis otitis media cervical adenitis
Typical Clinical featureswue (ta Sand ilin, physi R latent period o between infection and the onset of acute glomerulonephritis 1-2 weeks after a throat infection 3-6 weeks after a skin infection at the same time more likely to be IgA nephropathy
Typical Clinical features --- latent period ♦ between infection and the onset of acute glomerulonephritis. 1-2 weeks after a throat infection 3-6 weeks after a skin infection. ♦ at the same time : more likely to be IgA nephropathy
ypical clinical features hematuria(血尿) May be microscopic and not identified by the patient, in more than two thirds of cases May be macroscopic and lead to 正常尿色洗肉水样烟灰样 榨鱼 dark brown or tea- or cola colored urine This is often the first clinical symptom. caused by hemolysis of red blood cells that have penetrated the glomerular basement membrane and have passed into the tubular
Typical Clinical features ---hematuria（血尿） ➢ May be microscopic and not identified by the patient , in more than two thirds of cases ➢ May be macroscopic and lead to dark brown or tea-, or colacolored urine ♦ This is often the first clinical symptom. ♦ caused by hemolysis of red blood cells that have penetrated the glomerular basement membrane and have passed into the tubular system
Typical Clinical features edema o result of salt and water retention ◆ acute onset mild to modest severity ◆ pitting edema starts in the eye lids and face then the lower and upper limbs then generalized (Hydrocele, ascites. 4353PM Pericardial and pleural effusion. may be migratory: appear in eyelid in the morning, disappear in the afternoon and reappear around the ankle in the ambulant patients by the end of the day
Typical Clinical features --- Edema ◆ result of salt and water retention ♦ acute onset ♦ mild to modest severity ♦ pitting edema ♦ starts in the eye lids and face then the lower and upper limbs then generalized (Hydrocele, ascites. Pericardial and pleural effusion.) ♦ may be migratory: appear in eyelid in the morning, disappear in the afternoon and reappear around the ankle in the ambulant patients by the end of the day