上游充通大 SHANGHAI JIAO TONG UNIVERSITY 国Kappa r e S edation ·A nalgesia(spinal) ·M iosis
Kappa κ • S edation • A nalgesia (spinal) • M iosis
上游充通大 SHANGHAI JIAO TONG UNIVERSITY Delta 6 analgesia (spinal supraspinal) release of growth hormone SigmaΣ dysphoria(opposite of euphoria) o hallucination (both visual auditory) respiratory and vasomotor stimulation mydriasis
Delta δ • analgesia (spinal & supraspinal) • release of growth hormone Sigma Σ • dysphoria (opposite of euphoria) • hallucination (both visual & auditory) • respiratory and vasomotor stimulation • mydriasis
上游充通大粤 OPIOID receptors SHANGHAI JIAO TONG UNIVERSITY CNS distribution is not uniform they are at areas concerned with pain receptor locations beginning with highest concentration areas 1.cerebral cortex 2.amygdala Extracellular 3.septum 4.thalamus 5.hypothalamus 的你 6.midbrain 00 7.spinal cord 豪酵餐 Cytoplasmic HOOC 00000000000000000000000000
OPIOID receptors CNS distribution is not uniform they are at areas concerned with pain receptor locations beginning with highest concentration areas 1. cerebral cortex 2. amygdala 3. septum 4. thalamus 5. hypothalamus 6. midbrain 7. spinal cord Extracellular Cytoplasmic NH 2 Extracellular Cytoplasmic NH 2 HOOC
上游究通大学 SHANGHAI JIAO TONG UNIVERSITY RECEPTOR ENDOGNEOUS RECEPTOR LIGAND SUBTYPES Mu B-Endorphin 1 2 Kappa Dynorphins K1 K2 K3 Delta Enkephains 81 62
Proopiomelanocortin Proenkephalin Morphine CH3 6o00000000o0000000000002 β-Lipotropin 00000 C00000000000000000 00000 HO OH 00000 0000000000000c0000 0000C 00000 Enkephalin B-Endorphin Opioid receptors CH,-CH=CH2 K+-permeability↑ Ca2+-influx↓ Excitability↓ Release of transmitters↓ HO HO O Naloxone