6. Ketones from the reaction of nitriles with RMgX or rli N+ MaX H2o R—c三N+R"MgX—-R R R R" N R—c≡N+RLi—R R"—R R N MgBr c≡N+C6H5MgBr—-Ph Ph ph HaO Ph——c EN+n-BuLi→Ph CH2 CH2 CH2CH3 CH CH2CH2 CH2CH
6. Ketones from the reaction of nitriles with RMgX or RLi R C N + R'MgX R N + MgX - R' H3O+ R O R' R C N + R' Li R N + Li - R' H3O + R O R' C N + Ph N + MgBr - Ph H3O + Ph O Ph Ph C N + Ph N + Li - CH2CH2CH2CH3 H3O + C6H5 O CH2CH2CH2CH3 C6H5MgBr n-BuLi
16.6 Nucleophilic addition to the carbon-oxygen double bond Nucleophilic addition R8/8-88 R o H-Nu OH Nu Nucleophilic reagent
16.6 Nucleophilic addition to the carbon-oxygen double bond R H O + H-Nu + − R H OH Nu + − Nucleophilic addition Nucleophilic reagent