Rabies Transmission by the bite of a rabid animal commonly a dog or a cat the contamination of scratch wounds by virus-infected saliva Clinical findings Incubation/prodromal period 1 to 3 months · cns infection Hydrophobia. This fear of water is the result of the pain associated with drinking · Seizures and hallucinateⅰons. Paralysis may lead to respiratory failure Coma Mortality is >99%. Most deadly virus!
• Incubation/prodromal period 1 to 3 months • CNS infection • Hydrophobia. This fear of water is the result of the pain associated with drinking. • Seizures and hallucinations. • Paralysis may lead to respiratory failure. • Coma • Mortality is >99%. Most deadly virus! Transmission – by the bite of a rabid animal (commonly a dog or a cat) – the contamination of scratch wounds by virus- infected saliva. Clinical findings Rabies
Pathogenesis 5. Brain infected 6 Virus travels fom brain via nerves to other tissues such as eye, kidneys, salivary glands 4. Virus replicates in dorsal root ganghion 3 Virus infects nerve in and travels up spinal cord to brain peripheral nervous system Moves by retrograde 1. Virus enters transport via anmal bite 2. Virus replicates in muscle at site of bite
Pathogenesis