指x旁学命 分子诊断-1: Methods in Molecular medicine 张咸宁 zhangxianning@zju.edu.cn Tel:13105819271;88208367 Office: C303. Teaching Building 2014/09
分子诊断-1: Methods in Molecular Medicine 张咸宁 zhangxianning@zju.edu.cn Tel：13105819271; 88208367 Office: C303, Teaching Building 2014/09
Trends of Medicine in 21th Century “5P医学”: Prediction、 Prevention、 Participation Personalization Precision Treatment afterward Predictive Preventive General Personalized Molecular epidemiology: Sub-population Rare disease>Common diseases TME 能E
Trends of Medicine in 21th Century • “5P医学”: Prediction、 Prevention、 Participation、 Personalization、 Precision – Treatment afterward →Predictive & Preventive – Molecular epidemiology: Sub-population – Rare diseases → Common diseases – General →Personalized
In times of transformation we are all students O predict individual susceptibility to disease, based on genetic genomic, and other factors provide more useful tools and individualized programs for disease prevention, based on knowledge of one's susceptibility o detect the onset of disease earlier and before it is clinically evident based on newly discovered biological markers that arise from changes at the molecular level O preempt disease progression, as a result of early detection; O target medicines and their dose more precisely and safely to each patient, on the basis of a deep understanding of disease mechanism and the role that genetic and genomic factors play in the individual response to drugs Ginsburg GS, Willard HF essentials of Genomic and Personalized Medicine. Elsevier, 2010
In times of transformation, we are all students！ ● predict individual susceptibility to disease, based on genetic, genomic, and other factors; ● provide more useful tools and individualized programs for disease prevention, based on knowledge of one’s susceptibility; ● detect the onset of disease earlier and before it is clinically evident, based on newly discovered biological markers that arise from changes at the molecular level; ● preempt disease progression, as a result of early detection; ● target medicines and their dose more precisely and safely to each patient, on the basis of a deep understanding of disease mechanism and the role that genetic and genomic factors play in the individual response to drugs. ----Ginsburg GS, Willard HF. Essentials of Genomic and Personalized Medicine. Elsevier, 2010
Areas of Application of Molecular Diagnosis Infectious Disease Neoplastic Disease Genetic Disease Identity Testing HLA Typing Pharmacogenetics
Infectious Disease Neoplastic Disease Genetic Disease Identity Testing HLA Typing Pharmacogenetics Areas of Application of Molecular Diagnosis
China's birth defect(出生缺陷)rate (卫计委公布,S印P,2012) Birth defect: A congenital abnormality(先天性 畸形. Not all are detected at birth or even soon after 5.6% 16 million neonates(新生儿)/yr→ 1900000 affected, 270000 visible at birth
China‘s birth defect（出生缺陷）rate （卫计委公布，Sep., 2012） • Birth defect: A congenital abnormality (先天性 畸形). Not all are detected at birth or even soon after. • ~5.6% ~16 million neonates（新生儿）/yr → ~900 000 affected, ~ 270 000 visible at birth