Special Circulation Qang×A(夏强),PhD Department of Physiology School of medicine Te:88206417,88208252 Email:xiaqiang@zju.edu.cn
Special Circulation Qiang XIA (夏强), PhD Department of Physiology School of Medicine Tel: 88206417, 88208252 Email: xiaqiang@zju.edu.cn
System Overview The blood flow to organs depends on 1. The difference between aortic pressure and central venous pressure 2. The diastolic and systolic state of blood vessel in this organ The blood flow to individual organs must vary to meet the needs of the particular organ, as well as of the whole body
System Overview ➢ The blood flow to organs depends on ⒈ The difference between aortic pressure and central venous pressure ⒉ The diastolic and systolic state of blood vessel in this organ ➢ The blood flow to individual organs must vary to meet the needs of the particular organ, as well as of the whole body
System Overview Neural, myogenic, metabolic, and endothelial mechanisms control regional blood flow >Neural mechanism. Blood pressure Autonomic nervous system-+ Cardiac output (sympathetic division) Local blood flow >Myogenic mechanism: Autoregulation in the vessels of heart, brain, skeletal muscle, and kidneys >Metabolic mechanism: Local control in the vessels of heart PO2, pH, etc >Endothelial mechanism NO, EDHF, PGI2, ET, EDCF, etc Relaxing or contracting VSMCS
Neural, myogenic, metabolic, and endothelial mechanisms control regional blood flow ➢Neural mechanism: Autonomic nervous system (sympathetic division) ➢Myogenic mechanism: ➢Metabolic mechanism: PO2 , pH, etc. ➢Endothelial mechanism: NO, EDHF, PGI2 , ET, EDCF, etc. System Overview Autoregulation in the vessels of heart, brain, skeletal muscle, and kidneys Blood pressure Cardiac output Local blood flow Local control in the vessels of heart, brain, skeletal muscle during exercise Relaxing or contracting VSMCs
System Overview Sophisticated feedback, >Neural mechanism. Mechanical forces, etc Autonomic nervous system Local circulation (sympathetic division) Resting vasomotor tone >Myogenic mechanism: Vasomotor control >Metabolic mechanism. Electrical and chemical signalling PO2, pH, etc /SMCs→ ECS >Endothelial mechanism NO, EDHF, PGI2, ET, EDCF, etc Gap junction
➢Neural mechanism: Autonomic nervous system (sympathetic division) ➢Myogenic mechanism: ➢Metabolic mechanism: PO2 , pH, etc. ➢Endothelial mechanism: NO, EDHF, PGI2 , ET, EDCF, etc. System Overview Resting vasomotor tone ECs VSMCs Gap junction Electrical and chemical signalling Vasomotor control Sophisticated feedback, Mechanical forces, etc. Local circulation
Coronary circulation 冠脉循环 Copyright OThe MeGraw-Hill Cs Aorta Right coronary artery Left coronary artery Posterior inter-Marginal Anterior into ventricular circumflex ventricular er. artery artery artery artery Walls of Walls of Ventricular right atrium left atrium Ventricular walls and right and left walls ventricle ventricle Cardiac veins Coronary sinus Right atrium
Coronary circulation 冠脉循环