Immune Complex-mediated Renal Disease Planted antigen attracts its antibody from the circulation and a local immune complex IS Tormed. Immune complex localizes in the mesangium, glomerular capillary wall, or renal interstitium as a lumpy- bumpy pattern Small immune complexes are less likely to be deposited, and large immune complexes are preferentially removed by res minimizing localization in the kidney As circulating immune complexes are formed and antibody production increases the size of the circulating immune complex increases removal from the circulation by res cells or localization in the mesangium or glomerular capillary wall Various endogenous and exogenous substances may function as antigen in immune complex formation endogenous nuclear proteins in DNA-anti-DNA Ic in lupus nephritis, streptococcal cell wall antigens in post-streptococcal glomerulonephritis
Immune Complex-mediated Renal Disease • Planted antigen attracts its antibody from the circulation, and a local immune complex is formed. • Immune complex localizes in the mesangium, glomerular capillary wall, or renal interstitium as a lumpy-bumpy pattern. • Small immune complexes are less likely to be deposited, and large immune complexes are preferentially removed by RES minimizing localization in the kidney. • As circulating immune complexes are formed and antibody production increases, the size of the circulating immune complex increases: – removal from the circulation by RES cells or – localization in the mesangium or glomerular capillary wall. • Various endogenous and exogenous substances may function as antigen in immune complex formation. – endogenous nuclear proteins in DNA-anti-DNA IC in lupus nephritis, streptococcal cell wall antigensin post-streptococcal glomerulonephritis
basement membrane soluble antigen-antibody complexes 或Y endothelial cell