Humoral Immune response Jianzhong Chen, Ph.D. Institute of Immunology, ZJU
Jianzhong Chen, Ph.D. Institute of Immunology, ZJU
B cell-mediated humoral Immune response o Humoral immunity is mediated by antibodies and is the arm of the adaptive immune response that functions to neutralize and eliminate extracellular microbes and microbial toxins eIt is more important than cellular immunity in defending against microbes with capsules rich in polysaccharides and lipids, and against polysaccharide and lipid toxins
B cell-mediated humoral immune response Humoral immunity is mediated by antibodies and is the arm of the adaptive immune response that functions to neutralize and eliminate extracellular microbes and microbial toxins. It is more important than cellular immunity in defending against microbes with capsules rich in polysaccharides and lipids, and against polysaccharide and lipid toxins
1. Phases and types of humoral Immune responses 1)Phases o Antigen recognition phase Activation, proliferation and differentiation phase ● Effector phase 2) Types ° Response to TD-Ag Response to TI-Ag
1. Phases and types of humoral immune responses 1) Phases Antigen recognition phase Activation, proliferation and differentiation phase Effector phase 2) Types Response to TD-Ag Response to TI-Ag
Antigen Activation of Effector phase recognition B lymphocytes Effector cells antibody secreting Helper T cells cells other stimuli Antibody Clonal secretion Naive IgM+ IgD+ expansion o IgG IgG B cell →-的 celle Class switching Activated B cell Microbe →◎x Affinity maturation High-affinit Ig-expressing B cell High Affinity IgG Memory B cell (ElsevierAbbas&LichtmanBasicImmunologyupDated2e-www.studentconsult.com Phases of humoral immune responses
Phases of humoral immune responses Effector phase
2. Response to TD-Ag
2. Response to TD-Ag