(regional blood flow and affinity of drugs with tissues ② physicochemical characteristicS ●③ protein binding the binding is reversible and there is a dynamic equilibrium between the bound and unbound forms of a drug
⚫ ①regional blood flow and affinity of drugs with tissues ⚫ ② physicochemical characteristics ⚫ ③ protein binding ※ the binding is reversible and there is a dynamic equilibrium between the bound and unbound forms of a drug
d+B+P+DP ●※ Bound drug is not effective and serve as a substantial drug reservoir ※ The drugs with similar physicochemical characteristics compete with each other for the biding site and result competitive inhibition
⚫ D D + P DP ⚫ ※ Bound drug is not effective and serve as a substantial drug reservoir ⚫ ※ The drugs with similar physicochemical characteristics compete with each other for the biding site and result competitive inhibition