PLP O-P-o CH2 NB OH CHa CH Pyridoxal phosphate H (PLP) Enz LyE-NH? NH OH CHa Hgo O-P CHa H H2N CH E NH Pyridoxamine phosphate OH CHa
PLP
Oxidative deamination of glutamate GTP C00 C00 H N-C-H NAD(P)++NAD(P)H+H C=0 CHy +HO CH, NI glutamate dehydrogenase CH cOO Ghu utamate a-Ketoglutarate
Oxidative deamination of glutamate
glutaminase NHs CCH。 CHo-CH一COO HoN Glutamine gfutaminnee Ho liver mitochondnal NH4一 Urea NH3 C-CHo-CHo-CH--COo Glutamate
glutaminase
Amino acid oxidases H-C-NHy+ FMN+ H20 -c=0 FMNH NH, N COO c00 Amino acid a-Keto acid
Amino acid oxidases NH3
Metabolism of phenylalanine NH. Pheny tetrahydrobiopterin Phenylalanine hydroxylase Dihydrobiopterin NIc|H COo Tyrosine cx-Keto acid andse cx-Arrinho acid" H CHa COo P-Hydroxyphenyt pyruvate p-Hydroxypneny/ pyruvate hydroxylase HO Homogentisate COo Homogentisate oxidase unarate acetoacetate
Metabolism of phenylalanine 四 氢 生 物 蝶 呤