Chronically, bleeding in hemophilic can Compromise joint function and lead to accelerated dD (hemophilic arthropathy) Lead to pseudotumor formation Weaken muscles Lead to permanent neurologic compromise
Chronically, bleeding in hemophilics can • Compromise joint function and lead to accelerated DJD (hemophilic arthropathy) • Lead to pseudotumor formation • Weaken muscles • Lead to permanent neurologic compromise
Other complications of hemophilia Inhibitor formation Viral (and other) Infections · Job bias
Other complications of hemophilia • Inhibitor formation • Viral (and other) Infections • Job bias
Inhibitors in Hemophilia Are alloantibodies formed against Factor Vlll(and less commonly FiX in patients with congenital hemophilia Inactivate exogenously administered clotting factor Must be treated with bypassing agents which less efficacious in hemostasis Increase morbidity and mortality
Inhibitors in Hemophilia • Are alloantibodies formed against Factor VIII (and less commonly FIX) in patients with congenital hemophilia • Inactivate exogenously administered clotting factor • Must be treated with bypassing agents which less efficacious in hemostasis • Increase morbidity and mortality
Complications -Orthopedic Hemophilic arthropathy Surgeries synovectomy-arthroscopic or isotopic joint fusion-arthrodesis joint replacement-arthroplasty
Complications - Orthopedic • Hemophilic arthropathy • Surgeries – synovectomy - arthroscopic or isotopic – joint fusion - arthrodesis – joint replacement - arthroplasty
omplications-viral infection HIV and hepatitis B and c blood donation steps to improve viral safety of plasma-derived products 1. blood donors screened 2. donated blood tested for antibodies to hepatitis and hiv 3. all factor concentrate products are virally inactivated and purified
Complications - Viral infection • HIV and hepatitis B and C • Blood donation steps to improve viral safety of plasma-derived products 1. blood donors screened 2. donated blood tested for antibodies to hepatitis and HIV 3. all factor concentrate products are virally inactivated and purified