3.3 The role of survival factors and cell death in adjusting the number of developing nerve cells to the amount of target tissue apoptotic nerve cells nerve cells nerve cell body CELL DEATH nerve ADJUSTS cell NUMBER OF axon NERVE CELLS TO SIZE OF TARGET target cells survival factor released by target cells 11 This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
4.Molecular mechanisms of apoptosis C.elegans:1090 cells,131 cells dead. The Finding of Ced3 mutant, without any of their cells to apoptosis. 0.2mm Ced3 gene play a crucial role C elegans:a millimeter long, in the process of apoptosis. transparent body only a few cell types,from zygote to mature adult within 3.5 days. https://en.wikipedia.org/wiki/Caenorhabditis_elegans This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
线虫体细胞调亡研究：PCD相关基因15个，分为四组： 1.与PCD有关的基因，负责PCD控制：ced-3、ced-4和ced-9。 2.与PCD过程吞噬作用有关：ced-1、ced-2、ced-5-8和ced-1。 3.核酸酶基因（nuC-1),控制DNA降解，但非PCD所必须。 4.影响特异细胞类型PCD的基因：ces-1、ces-2、cgl-1、和 her-1. 保守性高，在哺乳动物中有相应同源物： Ced-3=ICE,Ced-4=Apaf-1,Ced-9=Bcl-2. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
4.1 Apoptosis is carried out by a proteolytic system ---caspase Why called caspase? Active site:Cysteine Cysteine Asparatic acid Cleavage site:Asparatic acid specific protease Asp-Xxx 天冬氨酸特异性的半光氨酸蛋白水解酶 This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
Three groups of caspase Apoptotic initiators: caspase-2,8,9 and caspase-10. Apoptotic executioners:caspase-3,6,7. Inflammatory mediators:caspase-1,11. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information