J aundice Definition Accumulation of yellow pigment in the skin and other tissues bilirubin)
Jaundice Definition Accumulation of yellow pigment in the skin and other tissues (Bilirubin)
Bilirubin metabolism a Bilirubin formation Transport of bilirubin in plasma Hepatic bilirubin transport s Hepatic uptake * Conjugation 冷 Biliary excretion Enterohepatic circulation
Bilirubin Metabolism ◼ Bilirubin formation ◼ Transport of bilirubin in plasma ◼ Hepatic bilirubin transport ❖ Hepatic uptake ❖ Conjugation ❖ Biliary excretion ◼ Enterohepatic circulation
Bilirubin formation 120ds RBCs-Senecent RBCs Iron hemoglo bin Globin Chiefly 70+% Bilirubin R Biliverdin CBR o heme Bilir 20% rubin nonhemoglobin heme Hepatic Hemoproteins nonhemoglobin hemoprotein 1-5% Premature destruction of newly formed rBCs
Bilirubin RBCs Senecent RBCs Iron hemoglobin Globin Bilirubin Biliverdin heme Hepatic Hemoproteins nonhemoglobin heme nonhemoglobin hemoprotein Premature destruction of newly formed RBCs C MHO R CBR 1-5% Chiefly 70+% 20% Bilirubin formation 120ds
Transport of Bilirubin in Plasma Albumin + UB+ UB- Albumin complex h afiinity binding sites 2:1/ Bilirubin Molar Plasma protein Ratio Albumin L affinity binding sites >2: 1 Bilirubin Other organic anions can be replaced b PHA UB↑
Transport of Bilirubin in Plasma Albumin + UB UB ~ Albumin Complex Molar Ratio Bilirubin Bilirubin Plasma protein Albumin H affinity binding sites L affinity binding sites can be replaced by Other organic anions PH UB 2:1 >2:1