National Cancer Institute (NCI)researcher Robert Gallo reports isolation of an AIDS virus he calls HILV-I11
National Cancer Institute (NCI) researcher Robert Gallo reports isolation of an AIDS virus he calls HTLV-III
Introduction Etiology and Pathogene: Virus ATLV HTLV-I HTLV-II HTLV-III Chemical substance Benzene poisoning lonizing radiation
• Etiology and Pathogenesis Virus ATLV HTLV-I HTLV-II HTLV-III Chemical substance Benzene poisoning Ionizing radiation Introduction
Introduction ·Pathogenesis Normal Stem cell mutation Leukemic stem cell Progenitor cells Blast cell
Introduction • Pathogenesis Normal Stem cell Blast cell Leukemic stemcell mutation Progenitor cells
Introduction 1)those that confer a proliferative or and survival KIT FLT3↑，NF-1↓ 2)those that impair hematopoietic differentiation and confer properties of self-renewal RUNX1-ETO,CBFB-SMMHC,TEL- RONX1 fusions mutation
Introduction • 1)those that confer a proliferative or and survival KIT FLT3 ↑， NF-1 ↓ • 2) those that impair hematopoietic differentiation and confer properties of self-renewal RUNX1-ETO,CBFB-SMMHC ,TELRONX1 fusions mutation
Introduction ·Properties of LSC: self-renewal,quiescent,proliferation,multi-potentiality?, differentiation damaged Immunophenotype of LSC AML CD34+CD38-CD71-CD90-CD117+CD123+,HLA- DR-; CML CD34+CD38-
Introduction • Properties of LSC: self-renewal,quiescent,proliferation,multi-potentiality? , differentiation damaged . Immunophenotype of LSC : AML CD34+CD38-CD71-CD90-CD117+ CD123+,HLADR-; CML CD34+CD38-