Pathogenesis PRIMARY INFECTION RECURRENT INFECTION LATENT RE-ACTNATION
Pathogenesis
Latency in trigeminal ganglia Active lesion on the lips HSV-1 or HSV-2
Clinical manifestations HSV is involved in a variety of clinical manifestations which includes Acute gingivostomatitis龈口炎 2. Herpes labialis( cold sore)唇疱疹 3. Ocular Herpes 4. Herpes Genitalis 5. Other forms of cutaneous herpes 7. Meningiti 8. Encephalitis 9. Neonatal herpes
Clinical Manifestations HSV is involved in a variety of clinical manifestations which includes ;- 1. Acute gingivostomatitis龈口炎 2. Herpes Labialis (cold sore)唇疱疹 3. Ocular Herpes 4. Herpes Genitalis 5. Other forms of cutaneous herpes 7. Meningitis 8. Encephalitis 9. Neonatal herpes
Oral-facial Herpes e Acute Gingivostomatitis Acute gingivostomatitis is the commonest manifestation of primary herpetic infection The patient experiences pain and bleeding of the gums. 1-8 mm ulcers with necrotic bases are present. Neck glands are commonly enlarged accompanied by fever Usually a self limiting disease which lasts around 13 days e Herpes labial is(cold sore) Following primary infection, 45% of orally infected individuals will experience reactivation. The actual frequency of recurrences varies widely between individuals Herpes labialis(cold sore)is a recurrence of oral Hs V. A prodrome of tingling, warmth or itching at the site usually heralds the recurrence. About 12 hours later, redness appears followed by papules and then vesicles
Oral-facial Herpes ⚫ Acute Gingivostomatitis – Acute gingivostomatitis is the commonest manifestation of primary herpetic infection. – The patient experiences pain and bleeding of the gums. 1 - 8 mm ulcers with necrotic bases are present. Neck glands are commonly enlarged accompanied by fever. – Usually a self limiting disease which lasts around 13 days. ⚫ Herpes labialis (cold sore) – Following primary infection, 45% of orally infected individuals will experience reactivation. The actual frequency of recurrences varies widely between individuals. – Herpes labialis (cold sore) is a recurrence of oral HSV. – A prodrome of tingling, warmth or itching at the site usually heralds the recurrence. About 12 hours later, redness appears followed by papules and then vesicles
