T-Dependent mechanism IL2 4-6 stimulate T-helper cells to multiply These t cells associate with b cells that have correct Ag MHC II complex and secrete B cell growth factors(BCGf that cause B cells to multiply BIOL 533 7 Lecture 7
BIOL 533 7 Lecture 7 T-Dependent Mechanism • IL2 4-6 stimulate T-helper cells to multiply – These T cells associate with B cells that have correct Ag— MHC II complex and secrete B cell growth factors (BCGF) that cause B cells to multiply
T-Dependent mechanism The number of b cells increase T-helper cells produce other cytokines(BCDF These cause some B cells to stop dividing, differentiating into plasma cells and produce ab Also B cell recognizes its Ag through its surface IgM receptor(signal #1 for b cell), subsequently triggered to proliferate plasma cells ab BIOL 533 Lecture 7
BIOL 533 8 Lecture 7 T-Dependent Mechanism • The number of B cells increase, T-helper cells produce other cytokines (BCDF) – These cause some B cells to stop dividing, differentiating into plasma cells and produce Ab – Also B cell recognizes its Ag through its surface IgM receptor (signal #1 for B cell), subsequently triggered to proliferate plasma cells Ab
T Cell Biology MHC molecules Major Histocompatibility Complex Found on plasma membrane Class i found on most nucleated body cells Class ii found only on leukocytes involved in immune response(macrophage, Ag presenting cells, B cells) Class i and Il Ag processed differently BIOL 533 Lecture 7
BIOL 533 9 Lecture 7 T Cell Biology • MHC molecules – Major Histocompatibility Complex – Found on plasma membrane – Class I found on most nucleated body cells – Class II found only on leukocytes involved in immune response (macrophage, Agpresenting cells, B cells) – Class I and II Ag processed differently