Endothelial cell GBM Epithelial cell (podocyte) Electron micrograph to show the filtration barrier Podocytes Kidney and urinary disease 6
Kidney and urinary disease 6 Electron micrograph to show the filtration barrier Podocytes Endothelial cell GBM Epithelial cell (podocyte)
Functions of the kidney 1.Keep the balance of total body fluid,electrolyte,acid and alkali. 2.Eliminate metabolic waste products in the body. 3.Remove foreign chemicals from the blood (e.g.drugs, pesticides,food additives.) Kidney and urinary disease
Kidney and urinary disease 7 Functions of the kidney ⒈ Keep the balance of total body fluid, electrolyte, acid and alkali. ⒉ Eliminate metabolic waste products in the body. ⒊ Remove foreign chemicals from the blood (e.g. drugs, pesticides, food additives.)
Functions of the kidney 4.Endocrine function: (1)Erythropoietin EPO erythrocyte stem erythrocytes cells Bone marrow Kidney and urinary disease 8
Kidney and urinary disease 8 Functions of the kidney ⒋ Endocrine function: ⑴ Erythropoietin erythrocyte stem cells erythrocytes EPO Bone marrow
Functions of the kidney 4.Endocrine function: (2)1a-hydroxylase 25a-hydroxylase 1a-hydroxylase enzyme enzyme Vitamin D 25(OH)D3 1,25(OH)2D3 skin liver kidney Kidney and urinary disease 9
Kidney and urinary disease 9 Functions of the kidney ⒋ Endocrine function: ⑵ 1α-hydroxylase skin kidney Vitamin D 25(OH)D3 1,25(OH)2D3 liver 25α-hydroxylase enzyme 1α-hydroxylase enzyme
Functions of the kidney 4.Endocrine function: (3)Renin Angiotensinogen Renin Angiotensin I ACE Angiotensin II Aldosterone Na", K+ Kidney and urinary disease 10
Kidney and urinary disease 10 Functions of the kidney ⒋ Endocrine function: (3) Renin Angiotensinogen Angiotensin Ⅰ Angiotensin Ⅱ Renin Aldosterone ACE Na+ , K+