讨论二 2、何药所致？停部分药物还是全部停用？ 异烟肼片？利福喷丁胶囊？吡嗪酰胺片？乙胺丁醇片？
讨论二 2、何药所致？停部分药物还是全部停用？ 异烟肼片？利福喷丁胶囊？吡嗪酰胺片？乙胺丁醇片？
药品说明书 异烟肼 利福喷丁 药品说明书 药品说明书 : 请仔细阅读说明书并在医生的指寻下使用 请仔细阅读说明书并在医生的指导下使用 【不良反应】 【不良反应】 发生率较多者有步态不稳或麻木针刺感、烧灼 感或手指疼痛（周围神经炎）；深色尿、眼或 本品不良反应比利福平轻微，少数病例可出现 乙胺丁醇 皮肤黄染（肝毒性：35岁以上患者肝毒性发生 白细胞、血小板减少；丙氨酸氨基转移酶升 率增高)；食欲不佳、异常乏力或软弱、恶心 高；皮疹、头昏、失眠等。胃肠道反应较少。 ← 药品说明书 或呕吐（肝毒性的前驱症状）。发生率极少者 应用本品未发现流感症候群和免疫性血小板降 情仔细阅读说明书并在医生的指导下使用 有视力模糊或视力减退，合并或不合并眼痛 【不良反应】 低，也未发现过敏性休克样反应。如果出现这 (视神经炎)；发热、皮疹、血细胞减少及男 发生率较多者为视力模糊、眼痛、红绿色盲或 性乳房发育等。本品偶可因神经毒性引起的抽 类不良反应须及时停药。 视力减退、视野缩小（视神经炎每日按体重剂 搐。 量25mg/kg以上时易发生)。视力变化可为 吡嗪酰胺 单侧或双侧； ← 药物警戒详情 : 发生率较少者为畏寒、关节肿痛（尤其大趾、 异烟肼可致胰腺炎、中毒性表皮 药品说明书 ◆ 髁、膝关节)、病变关节表面皮肤发热拉紧感 (急性痛风、高尿酸血症)； 坏死松解症、药物疹伴嗜酸粒细 请仔细阅读说明书并在医生的指导下使用 胞增多和系统症状 发生率极少者为皮疹、发热、关节痛等过敏反 【不良反应】 编通推程 应；或麻木，针刺感、烧灼痛或手足软弱无力 发生率较高者：关节痛（由于高尿酸血症引 (周围神经炎)。 美国FDA于2016年7月13日批准山德士 (Sandoz)公司的异烟肼（通用名： 起，常轻度，有自限性)；发生率较少者：食 Isoniazid,商品名：Isoniazid)片剂说明书修 订。 欲减退、发热、乏力或软弱、眼或皮肤黄染 在【不良反应】中增加：胰腺炎、中毒性表皮 (肝毒性)，畏寒。 坏死松解症、药物疹伴嗜酸粒细胞增多和系统 症状(DRESS)
药品说明书 异烟肼 利福喷丁 吡嗪酰胺 乙胺丁醇
利福喷丁 NCBI Resources☑How To⑨ Pub Med.gov PubMed Rifapentin erythema multiforme US Nationel Lbrary of Medion Create alert Advanced Article types Clinical Trial Search results Review Customize... Items:0 Text availability Abstract No documents match your search terms Free full tex对 Full text Pubmed上暂无利福喷丁致多形红斑的报 道
Pubmed上暂无利福喷丁致多形红斑的报 道。 利福喷丁
异烟肼 KansurzhogakuZassbi 2012 Jul:88(4):419-24. [A case of Stevens-Johnson syndrome(SJS)progressive toxic epidermal necrolysis(TEN)onset during hyposensitization therapy for pulmonary tuberculosis complicated with dermatomyositis]. [Article in Japanesel Yamashita H',Ueda Y.Takahashi Y,Mimori A. Author information 1 Division of Rheumatology.National Center for Global and Health Medicine. Abstract 重新进行药物诱导的淋巴细 A 58-year-old female with a history of dermatomyositis was receiving large oral doses of steroids.She had pulmonary tuberculosis and developed a fever,systemic exudative erythema,exanthema,and epidermolysis covering 30%of her body surface area while being treated with four agents,including isoniazid (INH)and rifampicin(RFP).Histopathologically,eosinophilic necrosis was observed in all layers of the 胞刺激试验(DLST)的可疑 epidermis and a diagnosis of Stevens-Johnson syndrome(SJS)progressive toxic epidermal necrolysis (TEN)was made.The drugs suspected in the drug-induced lymphocyte stimulation test(DLST)re-testing were INH and RFP,and the DLST was considered to be 药物是INH和RFP。 important during the recovery period as well as in the acute phase.Early treatment with plasma exchange therapy and large quantities of intravenous immunoglobulin (IVIG)was successful.Plasma exchange therapy and IVIG are extremely effective when SJS and TEN occur in a patient already on high-dose steroid therapy.Note that the incidence of SJS and TEN is believed to be higher in patients with collagen disease.such as in our case,as compared to the general population. Severe cutaneous adverse reactions due to isoniazid in a HIV positive patient. Viswanath BK'.Ranka P.Ramanjanayalu M. Author information 皮疹好转后再次试验性用 1 Department of Dermatology and JJ M Medical College.viswanath.bellulli@gmail.com Abstract 药，在再次使用异烟肼2天 Severe Cutaneous Adverse Reaction (SCAR)represents the spectrum of adverse drug reactions from erythema multiforme,Stevens- Johnson syndrome(SJS)to Toxic Epidermal Necrolysis (TEN).A 55 year old lady presented in a toxic state with peeling of skin,blisters on the body of seven days duration following medications taken for fever and pulmonary tuberculosis.When referred to our institution,she was 后，再次出现SJS。考虑为 diagnosed as TEN.Immediately the suspected medications were stopped.The essential investigations were done including the screening for immunosuppression.which was found to be negative.The patient was treated symptomatically with emphasis on skilled nursing care.The patient's skin condition improved gradually but tuberculosis progressively worsened over three months.Thus patient was reinvestigated for 异烟肼所致。 seropositivity and was found to be positive.Considering the benefit-risk ratio along with the advice of the pulmonologist.a decision was made to give her a rechallenge test.first for antitubercular drugs and later for antipyretics.The patient developed SJS within two days of starting isoniazid(INH).On withdrawal of INH the patient recovered. PMIn-234R4337
重新进行药物诱导的淋巴细 胞刺激试验（DLST）的可疑 药物是INH和RFP。 异烟肼 皮疹好转后再次试验性用 药，在再次使用异烟肼2天 后，再次出现SJS。考虑为 异烟肼所致
乙胺丁醇 Acta Dorm Venaredl2013Nov,9367534.ct10.234000015555-1600. A case of drug reaction with eosinophilia and systemic symptoms induced by ethambutol with early features resembling Stevens-Johnson syndrome. Kim JY'.Sohn KH.Song WJ.Kang HR. Author Information 1 Department of Internal Medicine.Seoul National University College of Medicine.Seoul.Korea. JAssoc Physicians India,2011 Jun;59:391-2. Ethambutol-induced toxic epidermal necrolysis. Chaudhary SC.Atam V.Gupta A.Arya R.Soni D
乙胺丁醇