AntifungalAgents Fungi are plant-like, nonphotosynthetic eukaryotes growing either on colonies of single cells(yeasts )or in filamentous multicellular aggregetes(molds). Most fungi live as saprophytes in soil or on dead plant materials and are important in the mineralization of organic matter. There are 300,000 kinds of fungi, but only 270 of which produce disease in humans and animals. These fungi are divided into two sections according mycotic illnesses in huamns they produced. That is: shallow fungi, produces skin and hair infections, system fungi, produces visceral infetions. In recent year, the incidence of fungal infections has reached alarming proportions. This duo to a number of factors such as intensive uses of chemotherapies for bacterial infection and cancers. The number of systemic infections have especially increased, this has been true for large populations of immunocompromized patients as well as those
Antifungal Agents Fungi are plant-like, nonphotosynthetic eukaryotes growing either on colonies of single cells(yeasts) or in filamentous multicellular aggregetes(molds).Most fungi live as saprophytes in soil or on dead plant materials and are important in the mineralization of organic matter. There are 300,000 kinds of fungi, but only 270 of which produce disease in humans and animals. These fungi are divided into two sections according mycotic illnesses in huamns they produced. That is:shallow fungi, produces skin and hair infections, system fungi, produces visceral infetions. In recent year, the incidence of fungal infections has reached alarming proportions. This duo to a number of factors such as intensive uses of chemotherapies for bacterial infection and cancers. The number of systemic infections have especially increased, this has been true for large populations of immunocompromized patients as well as those
Suffering from various hematological malignancies, acquired immun deficiency syndrome(AIDs) and patients undergoing organ transplantation So, to develop a new antifungal agents is a very important work. 暖祭伴下 面包上的毒 旺区且殖
Suffering from various hematological malignancies , acquired immune deficiency syndrome(AIDS) and patients undergoing organ transplantation. So, to develop a new antifungal agents is a very important work
5.1 The classification of antifungal agents Polyenes( Amphotericin) B Antimycotic antibiotics Others (Griseofulvin) Fluorinated pyrimidines(fluorocytosine) Imidazoles (ketoconazole) Az zoles Synthetic antifungal Triazoles fluoconazole) Allyamines (Terbinafine) Agents: Thioureas (Tolnafate Others (Ciclopirox)
5.1 The classification of antifungal agents: Antimycotic antibiotics: Synthetic antifungal Agents: Polyenes ( Amphotericin) B Others (Griseofulvin) Fluorinated pyrimidines (Fluorocytosine) Azoles Imidazoles (ketoconazole) Triazoles (Fluoconazole) Allyamines (Terbinafine) Thioureas (Tolnafate) Others (Ciclopirox)
The classification according to the actions of drugs Acetyl-CoA Squalene OXIdase +#-Allyamines(Thiocar bamates) Lanoste rol ←A Cytochrome 14 Demethy lanosterol P450 Ergosterol +#Polyenes (Mor phil ines) Cell membranes risofulvin∠-DNA Cell nucles Flucytosine Nucleic acid
Acetyl CoA Squalene Epoxidase Allyamines (Thiocarbamates) Lanosterol 14 Demethyllanosterol Cell membranes Ergosterol Cytochrome P 450 Azoles Polyenes (Morphilines) Cell nucles Grisofulvin Flucytosine DNA Nucleic acid The classification according to the actions of drugs
5.2 Antimycotic antibiotics 521 Ampotericin B(AMB)(两性霉素B) OH OH OH O OHOH OHoH O HOOC H 0 O NH OH OH AMB was marked in 1951s, is most commonly antibiotics used to treatment systemic fungal infections and is the only polyene antibiotic antifungal agents for injection use
5.2 Antimycotic antibiotics 5.2.1 Ampotericin B(AMB)(两性霉素B) O O O OH H HOOC OH OH OH OH OH OH OH O O CH3 OH NH2 OH AMB was marked in 1951’s, is most commonly antibiotics used to treatment systemic fungal infections and is the only Polyene antibiotic antifungal agents for injection use