Antibiotics Antibiotics are microbial metabilites or synthetic analogs inspired by them that, in small doses, inhibit the growth and survival of microorganism In clinic the antibiotics are used to be antibacterial mainly, but, in recent year, they can also be used for anti-cancer,anti- viral enzyme-inhibitors, and receptor-antagonist
Antibiotics Antibiotics are microbial metabilites or synthetic analogs inspired by them that,in small doses, inhibit the growth and survival of microorganism. In clinic the antibiotics are used to be antibacterial mainly,but, in recent year, they can also be used for anti-cancer,antiviral ,enzyme-inhibitors, and receptor-antagonist
Classification(According their structures) 1Beta- Lactam antibiotics(-内酰胺类) 2 Tetracylines antibiotics(四环素类) 3 Aminoglycoside antibiotics(氨基糖甙类) 4 Macrolides antibiotics(大环内酯类) 5. Others
Classification (According their structures)： 1.Beta-Lactam antibiotics (β –内酰胺类) 2.Tetracylines antibiotics (四环素类) 3.Aminoglycoside antibiotics (氨基糖甙类) 4.Macrolides antibiotics (大环内酯类) 5. Others
Classification (According to their mechanismof actions 1. Inhibit the biosynthesis of bacterial cell walls(B-lactam) 2. React with cell membrances (polymycin) 3. Disturber with the biosynthesis of protein(aminoglycosides) 4. Inhibit the replication and transcription of nucleonic acid (Nalicixic acid)
Classification (According to their mechanism of actions 1. Inhibit the biosynthesis of bacterial cell walls (β –Lactam) 2. React with cell membrances (Polymycin) 3. Disturber with the biosynthesis of protein (Aminoglycosides) 4. Inhibit the replication and transcription of nucleonic acid (Nalicixic acid)
分,为升胞浆膜细胞浆细胞壁孙制肥台成 肯素,头想茁素 (多粘酉 制 西素、忙褥素B 抑制DNA台成 喹诺类 蛋当历 影响叫酸代谢 (磺按类) 影啊蛋白蛋合成 愿婀RNA台成 (氨基甙员,环 (甲哌力复雄素) 累类、烈素 花素
1. B-Lactam Antibiotics The group of antibiotics known as the B-lactams include penicillins, cephalosporins, monobactams and the carbapenems N C-R COH COH Penicillin nucleus Cephalosporin nucleu HO N HC 5-R N SO.H COH Monobactam nucleus Carbapenem nucleus
1.*β –Lactam Antibiotics *The group of antibiotics known as the β-lactams include penicillins, cephalosporins, monobactams and the carbapenems