2. Other factorsearly marriedmultiparturitioncervical injuryoral contraceptiveeusegenital infectionassociatedcigarette smoking3. p53gene mutation
Sexual activityHPVexposureCervicaltransformationzoneSquamousepitheliumEndocervicalcolumnarepitheliumSquamousintraepitheliallesionHigh gradeLowgradeGlandularintraepitheliallesionHigh-riskHPVsLow-riskHPVs(adenocarcinomainsitu)6,11,42-4416,18,31,33,35High-risk HPVs16,18Smoking,oral contraceptives,highparity,alteredimmuneRarestatus,hostgenealterations,timeInvasiveInvasive SquamousAdenocarcinomaCarcinoma
二.Pathological changes1. Gross(1)Erosive type(2) Fungating typethe most commontypecauliflower or papillary(3)Infiltrative type(4)Ulcerating type
Fungating type公answer
2. Histological types(1)Squamous cell carcinoma:The most commontypeCervical epithelial dysplasiaCarcinoma in situinvasive carcinoma