(三)Pathologic types producingnephrotic syndrome(NS)Pathologic basis:(1)Massive proteinuriaywallInjury of capillaryIncreasedIpermeability tothe plasma protein
(三)Pathologic types producing nephrotic syndrome(NS) Pathologic basis: (1) Massive proteinuria Injury of capillary wall Increased permeability to the plasma protein
(2)HypoalbuminemiaHeayyproteinuriaDepletion of serum albumin
(2) Hypoalbuminemia Heavy proteinuria Depletion of serum albumin
(3)Generalized edema1)HypoalbuminemiaLoss of colloid osmotic pressure of bloodAccumulation of fluid in theinterstitial tissue
(3) Generalized edema ① Hypoalbuminemia Loss of colloid osmotic pressure of blood Accumulation of fluid in the interstitial tissue
②the capacity of bloodlfiltration of glomeruluslaldosterone and antidiuretichormone secretionsodiumandWater retention
②the capacity of blood↓ filtration of glomerulus↓ aldosterone and antidiuretic hormone secretion↑ sodium and water retention
lipiduria(4) Hyperlipidemia and-Hyperlipidemia:Hypoalbuminemiaincreased synthesis of lipoproteinintheliver-Lipiduria:injury of capillary wallpermeabbilityto lipiprotein
(4) Hyperlipidemia and lipiduria ▪ Hyperlipidemia: Hypoalbuminemia increased synthesis of lipoprotein in the liver ▪ Lipiduria: injury of capillary wall permeabbility to lipiprotein↑