二.Cervical epithelial dysplasiaand car.in situ1.Cervical epithelial dysplasiaThe part of cervicalepithelialwere replaced by atypical c withcancerative potentiality .lesionBelonging to precancerous
1.Cervical epithelial dysplasia The part of cervical epithelial were replaced by atypical c with cancerative potentiality . Belonging to precancerous lesion
2. Carcinoma in situEpithelial c were completelyreplaced by atypical c withoutcrossing the BM3. Cervical intraepithelialneoplasm (CIN)
2. Carcinoma in situ Epithelial c were completely replaced by atypical c without crossing the BM 3. Cervical intraepithelial neoplasm（CIN）
of CINGradingRange ofGradingDysplasiaprognosisinvolvementMild1/3 thicknessDisappearanceCIN Idysplasiaoflower layer(50%)can be cured1/2~2/3ModerateinvasiveCIN IIthickness ofdysplasiacarcinoma(2%)epithelium? Sever>2/3 thicknessInvasivedysplasiaofepitheliurmCIN III·Carcinomathe entirecarcinomain situthickness ofepithelium
Grading of CIN Grading Dysplasia Range of involvement prognosis CIN Ⅰ Mild dysplasia 1/3 thickness of lower layer Disappearance (50%) can be cured invasive carcinoma(2%) CIN Ⅱ Moderate dysplasia 1/2~2/3 thickness of epithelium CIN Ⅲ >2/3 thickness of epitheliurm the entire thickness of epithelium Invasive carcinoma • Sever dysplasia • Carcinoma in situ
NormalCINCIN IIIIICIN
Normal CIN Ⅰ CIN Ⅱ CIN Ⅲ
三.Cervical carcinoma(一)Etiologyy and Pathogenesis1. HPV infectionEpidemiologic datasexuallytransmittedagentHPV infection