ChapterThe disease ofcardiovascular system
Chapter 6 The disease of cardiovascular system
Section 1.Atherosclerosis (AS)Arteriosclerosis :Atherosclerosis（AS)Monckeberg media calcific sclerosisArteriolosclerosis
Arteriosclerosis : Atherosclerosis ( AS ) Monckeberg media calcific sclerosis Arteriolosclerosis Section 1. Atherosclerosis ( AS )
Atherosclerosis characterized by :IntimallesionscalledatheromaFibrofatty plaques that protrude into the lumenLoss of elasticity of underlying mediaUndergo a serious of complications
Atherosclerosis characterized by : Intimal lesions called atheroma Fibrofatty plaques that protrude into the lumen Loss of elasticity of underlying media Undergo a serious of complications
Primarily affects :Large-sized(elastic)arteriesaorta (abdominal),carotid arteriesMedium- sized muscular arteries :coronary,cerebral,poplitealA
Primarily affects : Large - sized (elastic) arteries : aorta (abdominal) , carotid arteries Medium - sized muscular arteries : coronary , cerebral , popliteal A
一.Etiology and PathogenesisRiskfactors一1. Hyperlipidemia :DLDLcholesterol,VLDL,triglyceridesLp (a)promotingHDL/HDL-C, apoA-I→ inhibiting2. Hypertension: a major risk factor
一 . Etiology and Pathogenesis (一) Risk factors 1. Hyperlipidemia : ① LDL cholesterol, VLDL, triglycerides Lp (a) promoting ② HDL/HDL-C, apoA-I inhibiting 2. Hypertension: a major risk factor