Hydrolysis of DNA and RNAunderalkalineconditionsRNAisrapidlyhydrolyzedduetothepresenceof2'-hydroxylgroups-DNAisnotrapidlyhydrolyzed2',3*-CycliMixtureof2'ohatderivatinderhvatiRNAIN
Oligonucleotides andPolynucleotidesoligonucleotide=short(typically<50 nucleotides)nucleicacidpolynucleotide=longernucleicacid
ThePropertiesof NucleotideBasesAffecttheThree-Dimensional Structureof Nucleic AcidsweaklybasiccompoundsaromaticmoleculesAdenineGuaninemostbondsintheringPurineshavepartialdouble-bondcharacterHUracilThymineCytosine(DNA)(RNA)Pyrimidines
Absorption Spectra of CommonNucleotidesall nucleotideAMP14,000basesabsorbGMP12,000UV lightUMP10,0008,000CMP6,000strong-dTMP4,000absorption2,000near260nm230240250/260270280Wavelength (nm)
Solubility of NucleotideshydrophobicandrelativelyinsolubleinpH7.0waterleadstostackinginteractions(vanderWaalsanddipole-dipole)chargedandmoresolubleatacidicoralkalinepHvalues