Molecular, cellular Tissue biomechanics Patrick Doyle(ChemE), Roger Kamm ME Be Maxine Jonas( BE) Goal: Develop a fundamental understanding of biomechanics over a wide range of length scales
Molecular, Cellular & Tissue Biomechanics Goal: Develop a fundamental understanding of biomechanics over a wide range of length scales. Patrick Doyle (ChemE), Roger Kamm (ME & BE) Maxine Jonas (BE)
MOLECULAR MECHANICS Biomolecules and intermolecular forces Single molecule biopolymer mechanics Ⅲl Formation and dissolution of bonds Motion at the molecular/macromolecular level ISSUE MECHANICS Molecular structure--> physical properties IL Continuum, elastic models(stress, strain, constitutive laws) Viscoelasticity Poroelasticity Electrochemical effects on tissue properties CELLULAR MECHANICS Structure/function/properties of the cell Biomembranes The cytoskeleton Cell adhesion and aggregation Cell migration Mechanotransduction
I Biomolecules and intermolecular forces II Single molecule biopolymer mechanics III Formation and dissolution of bonds IV Motion at the molecular/macromolecular level MOLECULAR MECHANICS I Structure/function/properties of the cell II Biomembranes III The cytoskeleton IV Cell adhesion and aggregation V Cell migration VI Mechanotransduction CELLULAR MECHANICS TISSUE MECHANICS I Molecular structure --> physical properties II Continuum, elastic models (stress, strain, constitutive laws) III Viscoelasticity IV Poroelasticity V Electrochemical effects on tissue properties
Typical Length Scales in Biology microtubule DNA WIdth width typical animal cell length of DNA in a chromosome human 10 10 -5 10 10 1↑10mees histone chromatin nucleus proteins width length of DNA contained in typical human ce‖l Similar spectra exist in time scales or energy scales
Typical Length Scales in Biology 10-9 10-7 10-5 10-3 10-1 101 meters human typical animal cell nucleus DNA width microtubule width length of DNA contained in a typical human cell chromatin width histone proteins length of DNA in a chromosome Similar spectra exist in time scales or energy scales
Muscles: Spanning from macro to nano Collection of myofibers Z disk Z disk Actin thin filament Myosin thick filament 000000 000 Myofiber (single cell 50 000 20099800000 Nucleus Plasma membrane Mlin Myofibril Sarcomere + A-band I band Z disk Actin: semiflexible polymer A band Myosin: molecular motor Titin: resting elasticity
Muscles: Spanning from Macro to Nano molecular motor semiflexible polymer Actin: semiflexible polymer Myosin: molecular motor Titin: resting elasticity
Macro-scale applications Cardiovascular mechanics 108 bpm 72 DDm Computational fluid mechanics used to study shear stresses in the carotid artery Image removed due to Image removed due to copyright considerations copyright considerations Peak floy Maximum Image removed due to Image removed due to copyright considerations copyright considerations deceleration
Cardiovascular mechanics Computational fluid mechanics used to study shear stresses in the carotid artery Peak flow Maximum deceleration 108 bpm 72 bpm Macro-scale applications Image removed due to copyright considerations. Image removed due to copyright considerations. Image removed due to copyright considerations. Image removed due to copyright considerations