Values of the elastic or youngs modulus for naterials SILK F-ACTIN TUBULIN TENDON WOOD CONTRACTED~SKELETALMUSCLE 1.E+06 YMA FIBROBLAST CELLS 1E+02 ENOOIIHELIAL MPHOCYIES Muscle plasma LUMEN BLOOD Connective tissue Connective tissue Basal lamin thelial cell
1.E+00 1.E+02 1.E+04 1.E+06 1.E+08 1.E+10 1.E+12 DIAMOND STEEL BONE CONCRETE SILK F-ACTIN TENDON WOOD TUBULIN CONTRACTED SKELETAL MUSCLE ELASTIN RELAXED SKELETAL MUSCLE COLLAGEN GELS LUNG PARENCHYMA FIBROBLAST CELLS ENDOTHELIAL CELLS NEUTROPHILS LYMPHOCYTES various materials Values of the elastic or Young’s modulus for 1 Basal laminae (the yellow lines) are organized in three ways
Right tibia( somewhat non- isotropic and nonlinear) BA-direction Radial direction Comments bayashi K Tanabe Y, KO Anni Mech 4 human compact bone, Theor A Striated A-resting Microscopic B- max contraction sarcomere level 她时行苗m
Right tibia (somewhat nonisotropic and nonlinear) Longitudinal direction Radial direction Microscopic - sarcomere level Striated muscle Macroscopic view A - resting B - max contraction C - active component 2
molecule with an optical tweezer -rap center XY stage Laser light The force-extension curve of a single collagen ll 50100150200150300 Extensions(nm) Table 22-4. Major Collagen Molecules Type Molecule Composition Structural features Ial(Dl[a2(D1 300-nm-long fibrils Skin tendon bone ligaments, dentin. 300-mmm long fibrils Le, vireou 00-lnm-long fibrils: often Skin, muscle blood v Ial(v)l 390-pm-long fibrils with vi [a levI a(VI) Lateral association with type Most mt Ix [aI(LX)Il a2(x)ll a 3(Ix)| Lateral association with type Cartilage. humor iy la lvillazavol Two-dimensional network All basal laminae SOURCE: K Kuhn, 1987, in R. Mayne and R Burgeson, eds, Strcture and Functi Collagen Types. Academic Press, P. 2: M van der Res and R. Garrone. 1991
3
Image removed due to copyright considerations See Figure 19-41 in: Alberts, Bruce, et al. Molecular Biology of the Cell. 4th ed. New York: Garland Image may be viewed online at the NIH's PubMed Bookshelf. http://www.ncbi.nim.nihgov/entrez/query.fcgi?db=books 1 synthesis of pro-a chain Sell-assembly of three ER/Golgi Compartmen Collagen fibril 一→0 Secretory vesicle eps y and g are now thought to occur traceMtany, at least a some tissues. Events involved in the formation of a collagen fibril
4 Image removed due to copyright considerations. See Figure 19-41 in: Alberts, Bruce, et al. Molecular Biology of the Cell. 4th ed. New York: Garland Publishing, 2002. Image may be viewed online at the NIH's PubMed Bookshelf. Events involved in the formation of a collagen fibril. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Books
Image removed due to copyright considerations. See Figure 7.3: 4 in: Fung, Y C. Biomechanics: Mechanical Properties of Living Tissues. New York: Springer-Verlag, 1993 Ice fibrils Light staining region Gap between individual with no gaps molecule Heavy metal stain
5 Image removed due to copyright considerations. See Figure 7.3:4 in: Fung, Y. C. Biomechanics: Mechanical Properties of Living Tissues. New York: Springer-Verlag, 1993. Striated appearance of collagen fibrils