Sy AGAACA n TGTTCT n=3 GR-GR PR-PR AR-AR MR-MR b)Direct repeats AGGTCA n AGGTCA RXR RXR RAR PPAR COUP n=2 RXR PPAR RevErb-RevEro = RXR- VDR VDR-VDR n=4 RXR- TR LXR CAR n= RXR- NGFI-B (c)Monomeric sites XXX-AGGTCA xxx= aaa NGFI-B xXx= act RevErb
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES
DR3 DR4 心 DR5 A司
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES
CTE cognition helix Conserved CTEs RevErb
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES
The model of nuclear receptor regulating gene expression Ligand Nuclear Receptor Coactivator Chromatin and basic transcriptional Hormone response Element①N
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES Hormone Response Element (DNA) Coactivator Chromatin and basic transcriptional machinery The model of nuclear receptor regulating gene expression Nuclear Receptor Ligand
核受体辅因子( cofactor) Co-activators Upon binding of agonist the receptor changes its conformation in the ligand-binding domain that enables recruitment of co-activators, which allows the receptor to interact with basal transcriptional machinery more efficiently and to activate transcription Examples: SRC-1, GRIPl, RIP140, (PNRC) NR bOX: LXXLL O-repressors The unliganded receptors are shown to inhibit basal promoter activity; this silencing of target gene transcription by unliganded receptors mediated by interacting with co-repressors Examples: N-CoR, SMRT
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES Co-activators Upon binding of agonist the receptor changes its conformation in the ligand-binding domain that enables recruitment of co-activators, which allows the receptor to interact with basal transcriptional machinery more efficiently and to activate transcription. Examples: SRC-1, GRIP1, RIP140, (PNRC) NR box: LxxLL Co-repressors The unliganded receptors are shown to inhibit basal promoter activity; this silencing of target gene transcription by unliganded receptors is mediated by interacting with co-repressors. Examples: N-CoR, SMRT 核受体辅因子（cofactor）