岽徳崇竇 亦韩求新 脑活动细胞分子基础 以基底神经节环路活动为例 ZHANG Jun Department of Physiology
脑活动细胞分子基础 ——以基底神经节环路活动为例 ZHANG Jun Department of Physiology
Outlines >(一)脑活动概述 (二)神经环路活动:实现脑功能活动的保证 (三)神经环路活动的细胞分子基础—神 经元、突触、环路整合 (四)举例:基底神经节环路活动中黑质-纹状 体通路机制的研究进展和前沿
➢（一）脑活动概述 ➢（二）神经环路活动：实现脑功能活动的保证 ➢（三）神经环路活动的细胞分子基础——神 经元、突触、环路整合 ➢（四）举例：基底神经节环路活动中黑质-纹状 体通路机制的研究进展和前沿 Outlines
2014诺贝尔生理学或医学奖 ALFR / NOBEL tion, Photo Lovisa Engblom The Nobel Prize in Physiology or Medicine 2014 was divided, one half awarded to John O'Keefe, the other half jointly to May-Britt Moser and edvard moser "for their discoveries of cells that constitute a positioning system in the brain
2014诺贝尔生理学或医学奖 The Nobel Prize in Physiology or Medicine 2014 was divided, one half awarded to John O'Keefe, the other half jointly to May-Britt Moser and Edvard I. Moser "for their discoveries of cells that constitute a positioning system in the brain
2014诺贝尔生理学或医学奖 The Nobel Prize in Physiology or Medicine 2014 缦 John O'Keefe John o'Keefe discovered. in 1971. that certain nerve cells in the brain were activated when a rat assumed a particular place in the environment. Other nerve cells were activated at other places. He proposed that these "place cells"build up an inner map of the environment. Place celis are located in a part of the brain called the hippocampus. Fig. 1 May- Britt M。 ser and Edvard l. Moser 鱼急 Aay- Britt och Edvard l. Moser discovered in 2005 that other nerve cells in a nearby part of the brain, the entorhinal cortex, were activated when the rat passed certain locations. Together, these locations formed a hexagonal grid each"grid cell reacting in a unique spatial pattern. Collectively, these grid cell form a coordinate system that allows for spatial navigation Fig. 2
2014诺贝尔生理学或医学奖
2014诺贝尔生理学或医学奖 Grid cells, together with other cells in the entorhinal cortex that recognize the direction of the head of the animal and the border of the room form networks with the place cells in the hippocampus. This circuitry constitutes a comprehensive Fig 3 positioning system, an inner GPS, in the brain. The positioning system in the human brain appears to have similar components as those of the rat brain
2014诺贝尔生理学或医学奖