Nuclear receptors 学术关注度(1996-2008) 关键词搜索:核受体 197 1999 2001 2002 2005 学术关注度(1996-2008) 关键词搜索:转录因子 1998 1999 21 004 00s 2007
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES 核受体超家族是一类配体依赖性 转录因子,其成员广泛介导了与真核细 胞生长、发育和内环境稳定相关基因的 表达。 1、类固醇激素及其受体的作用机制 2、核受体超家族的组成和结构 Nuclear receptors 学术关注度(1996-2008) 关键词搜索:核受体 学术关注度(1996-2008) 关键词搜索:转录因子
inhibitory hormone-binding site protein complex COOH transcription activating domain H2N DNA-binding domain I hinge region steroid hormone DNA-binding site exposed H COOH
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES
Nuclear Hormone Receptor NUCLEUS (inactive) INACTIVE GENE Hormone Promoter Response CYTOSOL Element A Nuclear Hormone Receptor H。mone receptor dimer mRNA synthesis BLOOD Steroid Homone Control of Gene transcription
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES
CHOH HC 表6-12类固醇激素受体超家族的组成及性质 受体名称 分子量组成氨基因大小外显 与HSH90 kD基酸数(M)千数染色体定位细胞定位 结合 糖皮质激素受体CR 777 9 胞浆/核 盐皮质激素受体MR 胞浆/核 ●黄体素受体FR(A) 79 934 q22胞浆核 雄激素受体AR 98 918 >908Xq2-1浆/核 ●雌激素受体ER 595 胞浆/核 t,25(OH)2D受体VDR55427459 胞浆/核 T3受体T3Ral 40 I7q1-21胞浆/核 TRBI 52 456 >250 视黄酸受体RAR 17 (atRA)RAR &1 RAR 12 (9cRA)RXRo 467 RXRB 410 核核核核核核核 RXR 463
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES
Nuclear Receptor Superfamily AB D E DNA Ligandb-C AF-1 CTE DIMERIZATION AF-2 Steroid Receptors RXR Heterodimers TaR thyroid hormone d GR glucocorticoid RAR all-trans RA MR mineralcorticoid RXE R VDR 1,25-(OH)2VD PR progesterone PPAR a fatty acids AR androgen PPARY 15d-△12,14PGJ ER estrogen EcR ecdysone FXR bile acids CAR androstane LXR oxysterol PXR/SXR xenobiotics Dimeric Orphan Receptors Monomeric /Tethered Orphan Receptors RXR 9-cis RA NGFI-B COUP RXR SF-1 HNF-4 Rev-erb TR2 ROR TLX ERR GCNF
THIRD MILITARY MEDICAL UNIVERSITY COLLEGE OF BASIC MEDICAL SCIENCES