Sample of helix-Turn-Helix 入 repressor Turn Helix 2 Helix 3 Turn (b) Helix-turn -helix motif DNA Interaction between the n repressor dimer and DNA. Each 2 repressor contains a helix-turn-helix motif. One of helices fits into the major groove of DNA. PDB ID= ILMB
Sample of Helix-Turn-Helix Interaction between the l repressor dimer and DNA. Each l repressor contains a helix-turn-helix motif. One of helices fits into the major groove of DNA. PDB ID = 1LMB
Zinc finger motif锌指 C2H2 zinc finger: It is characterized by the sequence CX C. HXH, where C cysteine h= histidine, x- any amino acid. In the 3D structure two cysteine residues and two histidine residues interact with a zinc ion C4 Zinc finger: Its consensus sequence is CX2 CX13CX2CX14 I5 CXCX C. The first four cysteine residues bind to a zinc ion and the last four cysteine residues bind to another zinc ion( C6 Zinc finger. It has the consensus sequence CX2CXCX5 6CX2CXC. The yeast's Gal4 contains such a motif where six cysteine residues interact with two zinc ions
Zinc finger motif 锌指 • • C2H2 zinc finger: It is characterized by the sequence CX2- 4C....HX2-4H, where C = cysteine, H = histidine, X = any amino acid. In the 3D structure, two cysteine residues and two histidine residues interact with a zinc ion. • C4 zinc finger: Its consensus sequence is CX2CX13CX2CX14- 15CX5CX9CX2C. The first four cysteine residues bind to a zinc ion and the last four cysteine residues bind to another zinc ion (. •C6 zinc finger. It has the consensus sequence CX2CX6CX5- 6CX2CX6C. The yeast's Gal4 contains such a motif where six cysteine residues interact with two zinc ions
Zinc finger motif锌指 C2H2 zinc finger: It is characterized by the sequence CX2_4C.HX24H In the 3D structure, two cysteine residues and two histidine residues interact with a zinc ion C4 zinc finger: Its consensus sequence is CX2CX13CX2CX14-15CXSCXCX2C. The first four cysteine residues bind to a zinc ion and the last four cysteine residues bind to another zinc ion C6 Zinc finger. It has the consensus sequence CX, CX CX5. CX, CX, C. The yeast's Gal4 contains such a motif where six cysteine residues interact with two zinc ons
Zinc finger motif 锌指 • C2H2 zinc finger: It is characterized by the sequence CX2-4C....HX2-4H. In the 3D structure, two cysteine residues and two histidine residues interact with a zinc ion • C4 zinc finger: Its consensus sequence is CX2CX13CX2CX14-15CX5CX9CX2C. The first four cysteine residues bind to a zinc ion and the last four cysteine residues bind to another zinc ion • C6 zinc finger. It has the consensus sequence CX2CX6CX5-6CX2CX6C. The yeast's Gal4 contains such a motif where six cysteine residues interact with two zinc ions
C2H2 Zinc finger Cys The domain organization of Spl which consists of 696 residues The structure of a zinc finger region. PDB ID=ISPI
C2H2 zinc finger The domain organization of Sp1 which consists of 696 residues The structure of a zinc finger region. PDB ID = 1SP1