()Alcohol, USP: Ethyl Alcohol, Ethanol Alcohol is the most useful solvent in pharmacy next to water. USP is 94.9 to 96% C,Hoh by volume(i.e,v/v) Together with water it forms a hydroalcoholic water-soluble substances, a feature especial d mixture that dissolves both alcohol-soluble al useful in the extraction of active constituents from crude drugs
(1) Alcohol, USP: Ethyl Alcohol, Ethanol ◼ Alcohol is the most useful solvent in pharmacy next to water. USP, is 94.9 to 96% C2H5OH by volume (i.e., v/v) ◼ Together with water it forms a hydroalcoholic mixture that dissolves both alcohol-soluble and water-soluble substances, a feature especially useful in the extraction of active constituents from crude drugs
Alcohol has been well recognized as a solvent and excipient in the formulation of oral pharmaceutical products Certain drugs are insoluble in water and must be dissolved in an alternative vehicle Alcohol is frequently used with other solvents, such as glycols and glycerin, to reduce the amount of alcohol required
◼ Alcohol has been well recognized as a solvent and excipient in the formulation of oral pharmaceutical products. ◼ Certain drugs are insoluble in water and must be dissolved in an alternative vehicle. ◼ Alcohol is frequently used with other solvents, such as glycols and glycerin, to reduce the amount of alcohol required
a It also is used in liquid products as an antimicrobial preservative alone or with parabens, benzoates, sorbates, and other agents. However, concern has been expressed over the undesired pharmacologic and potential toxic effects of alcohol OTC Children under 6 years of age alcohol limit 0.5%o 6-12 years of age Over 12 years of age and adults 10%
◼ It also is used in liquid products as an antimicrobial preservative alone or with parabens, benzoates, sorbates, and other agents. ◼ However, concern has been expressed over the undesired pharmacologic and potential toxic effects of alcohol. Children under 6 years of age alcohol limit 0.5% 6-12 years of age 5% Over 12 years of age and adults 10% OTC
2)Diluted AlcohoL, NF a Diluted Alcohol, NF, is prepared by mixing equal volumes of Alcohol, USP, and Purified Water. USP The strength of Diluted Alcohol, NE, is not exactly half that of the more concentrated alcohol but slightly greater, approximately 49% a Diluted alcohol is a useful hydroalcoholic solvent in various pharmaceutical processes and preparations
(2) Diluted Alcohol, NF ◼ Diluted Alcohol, NF, is prepared by mixing equal volumes of Alcohol, USP, and Purified Water, USP. ◼ The strength of Diluted Alcohol, NF, is not exactly half that of the more concentrated alcohol but slightly greater, approximately 49%. ◼ Diluted alcohol is a useful hydroalcoholic solvent in various pharmaceutical processes and preparations
()Alcohol, Rubbing Rubbing alcohol contains about 70%o ethyl alcohol by volume, the remainder consisting of water, denaturants with or without color additives and perfume oils, and stabilizers 100ml denaturants Sucrose octaacetate 蔗糖八乙酸酯)355mg 8 parts acetone or(denatonium benzoate 1.5 parts methyl isobutyl ketone 地那铵苯甲酸盐14mg) 100 parts ethyl alcohol
(3) Alcohol, Rubbing ◼ Rubbing alcohol contains about 70% ethyl alcohol by volume, the remainder consisting of water, denaturants with or without color additives and perfume oils, and stabilizers. Sucrose octaacetate (蔗糖八乙酸酯） 355 mg or (denatonium benzoate 地那铵苯甲酸盐 1.4 mg) 100 ml 8 parts acetone 1.5 parts methyl isobutyl ketone 100 parts ethyl alcohol denaturants