Through selection of a different solubilizing agent or a different chemical salt form of the medicinal agent, alteration of the ph of a solution, or substitution in part or in whole of the solvent, a pharmacist can in certain instances dissolve greater quantities of a solute than would otherwise be possible
Through selection of ◼ a different solubilizing agent or ◼ a different chemical salt form of the medicinal agent, ◼ alteration of the pH of a solution, ◼ or substitution in part or in whole of the solvent, a pharmacist can in certain instances dissolve greater quantities of a solute than would otherwise be possible
Temperature is an important factor in determining the solubility of a drug and in preparing its solution. a Most chemicals absorb heat when they are dissolved and are said to have a positive heat of solution, resulting in increased solubility with a rise in temperature A few chemicals have a negative heat of solution and exhibit a decrease in solubilit with a rise in temperature
◼ Temperature is an important factor in determining the solubility of a drug and in preparing its solution. ◼ Most chemicals absorb heat when they are dissolved and are said to have a positive heat of solution, resulting in increased solubility with a rise in temperature. ◼ A few chemicals have a negative heat of solution and exhibit a decrease in solubility with a rise in temperature
Other factors including a the various chemical and other physical properties of both the solute and the solvent, pressure, the ph of the solution the state of subdivision of the solute, a and the physical agitation applied to the solution as it dissolves affect solubility
Other factors including ◼ the various chemical and other physical properties of both the solute and the solvent, pressure, ◼ the pH of the solution, ◼ the state of subdivision of the solute, ◼ and the physical agitation applied to the solution as it dissolves affect solubility
The solubility of a substance in a given solvent may be determined a by preparing a saturated solution of it at a specific temperature, a and determining by chemical analysis the amount of chemical dissolved in a given weight of solution
The solubility of a substance in a given solvent may be determined ◼ by preparing a saturated solution of it at a specific temperature, ◼ and determining by chemical analysis the amount of chemical dissolved in a given weight of solution
The solubility may be expressed as grams of solute dissolving in milliliters of solvent When the exact solubility has not been determined, general expressions of relative solubility may be used These terms are defined in the uSP and presented in Table 12.1
◼ The solubility may be expressed as grams of solute dissolving in milliliters of solvent. ◼ When the exact solubility has not been determined, general expressions of relative solubility may be used. ◼ These terms are defined in the USP and presented in Table 12.1