Suspected drug usage Two suspicious drugs >Cyclosporin:环孢素l0 years:Aplasticanemia纯红再障： >Atorvastatin阿托伐他汀5 years:Coronary heart diaease冠心病； Cyclosporin metabolism of Atorvastatin Diagnosis ADR of Atorvastatin plasma concentration of Atorvastatin increased Rhabdomyolysis横纹肌溶解症
Suspected drug usage Cyclosporin环孢素 10 years: Aplasticanemia Atorvastatin阿托伐他汀 5years：Coronary heart diaease Two suspicious drugs Cyclosporin metabolism of Atorvastatin plasma concentration of Atorvastatin increased 10 years: Aplasticanemia纯红再障： Coronary heart diaease冠心病 ; ADR of Atorvastatin Rhabdomyolysis 横纹肌溶解症 Diagnosis
Treatment withdraw drug --withdraw Atorvastatin
Treatment • withdraw drug ——withdraw Atorvastatin ！
hy drugs result in ADR easily in elderly? 13
Why drugs result in ADR easily in elderly ？ 13
Changes happened in elderly Physiological changes Pathological changes Pharmacokinetics Pharmacodynamics 14
Changes happened in elderly • Physiological changes • Pathological changes Pharmacokinetics Pharmacodynamics Changes happened in elderly 14