第十二章 核酸化学 ■ 第一节概述 第二节核酸的水解和组成 第三节 体内某些重要核苷酸 第四节 核酸的结构 ■第五节 核酸的理化性质
第十二章 核酸化学 n 第一节 概述 n 第二节 核酸的水解和组成 n 第三节 体内某些重要核苷酸 n 第四节 核酸的结构 n 第五节 核酸的理化性质
第一节概述 研究史： 1869 J.F.Miescher nuclein 1889 Altmann nucleic acid 1909 W.Johannsen gene 1910 T.H.Morgan role of the chromosome in heredity 1941 G.W.Beadle,E.L.Tetum one gene one enzyme 1944 O.Avery diplococcus pneumoniae transform 1953 J.Watson F.Crick DNA double helix 1966 R.W.Holley et al interpretation of the genetic code 1991 USA the Human Genome Project 1997 L.Wilmut et.al Dolly sheep 2001 USA,UK,France, Germany,Japan and China Human Genome Mapping 2002 Jun Yu et al Draft Sequence of the Rice Genome
第一节 概述 n 研究史： n 1869 J. F. Miescher nuclein n 1889 Altmann nucleic acid n 1909 W. Johannsen gene n 1910 T. H. Morgan role of the chromosome in heredity n 1941 G. W. Beadle , E. L. Tetum one gene one enzyme n 1944 O.Avery diplococcus pneumoniae transform n 1953 J.Watson F.Crick DNA double helix n 1966 R. W. Holley et al interpretation of the genetic code n 1991 USA the Human Genome Project n 1997 L. Wilmut et.al Dolly sheep n 2001 USA, UK, France, Germany, Japan and China Human Genome Mapping n 2002 Jun Yu et al Draft Sequence of the Rice Genome
James Watson (left)and Francis Crick
James Watson (left) and Francis Crick
The Nobel Prize in Physiology or Medicine 1962 "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material" Francis Harry James Dewey Maurice Hugh Compton Crick Watson Frederick Wilkins 味 9 Great Britain USA Great Britain Institute of Harvard University of Molecular University London Biology Cambridge,MA, London,Great Cambridge, USA Britain Great Britain 1916- 1928- 1916-
Francis Harry Compton Crick James Dewey Watson Maurice Hugh Frederick Wilkins Great Britain USA Great Britain Institute of Molecular Biology Cambridge, Great Britain Harvard University Cambridge, MA, USA University of London London, Great Britain 1916 - 1928 - 1916 - "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material" The Nobel Prize in Physiology or Medicine 1962
The Nobel Prize in Physiology or Medicine 1968 "for their interpretation of the genetic code and its function in protein synthesis" Robert W. Har Gobind Marshall W. Holley Khorana Nirenberg USA USA USA Cornell University of National Institutes University Wisconsin of Health Ithaca,NY, Madison,WI,USA Bethesda,MD,USA USA 1922-1993 1922- 1927-
Robert W. Holley Har Gobind Khorana Marshall W. Nirenberg USA USA USA Cornell University Ithaca, NY, USA University of Wisconsin Madison, WI, USA National Institutes of Health Bethesda, MD, USA 1922 - 1993 1922 - 1927 - The Nobel Prize in Physiology or Medicine 1968 "for their interpretation of the genetic code and its function in protein synthesis