1. Generation of Acid-Base 1)Sources of acid 1 volatile acid CO2+H20>H2CO3>H++HCO3 (H 15 mol /d) 2) fixed acid(non-volatile acid hosphoric sulfuric, lactic, ketone bodies etc H+0.05-0.10mol/d
1. Generation of Acid-Base (1) Sources of acid 1）volatile acid CO2 + H2O → H2CO3 → H+ + HCO3 - (H+ 15 mol /d) 2）fixed acid (non-volatile acid) phosphoric, sulfuric, lactic, ketone bodies etc. H+ 0.05 – 0.10 mol /d
Aerobic Anaerobic Oxidation of Incomplete Hydrolysis of respiration respiration sulfur-containing oxidation of phosphoproteins of glucose of glucose amino acids fatty acids and nucleic acids Carbonic Lactic Sulfuric Acidic ketone Phosphoric acid acid acid bodies acid Internal environment Sources of acid in body
Sources of acid in body
(2) Sources of bases 1) products of metabolism (small amounts Such as ammonia(nh3) 2)dietary intake (vegetables and fruits sodium citrate acids production >>bases, in commen renal reabsorption
(2) Sources of bases 1）products of metabolism （small amounts）Such as ammonia (NH3 ) 2）dietary intake（vegetables and fruits） sodium citrate *acids production >>bases, in commen *renal reabsorption
renal reabsorption pH 7.35-7.45 in Arterial blood
pH 7.35~7.45 in Arterial blood renal reabsorption
2. Henderson-Hasselbalch equation lHCO3 pH=pKa+lg H2CO31 20 pKa+lg =61+ lg hco3/0.03×PCO2 6.1+lg24/1.2=74 6.1+13=74 pH7.35~7.45
2. Henderson-Hasselbalch Equation pH=pKa+lg [HCO3 - ] [H2CO3 ] =pKa+lg 20 1 = 6.1 +1.3 = 7.4 pH 7.35~7.45 = 6.1 + lg HCO3 - / 0.03 × PCO2 = 6.1 + lg 24 / 1.2 = 7.4