Henderson-Hasselbalch Equation Acid-base balance is mainly the balance between production and loss of acid and base PH=PKa+l [HCO3] HH2cO3 20 pka+lg =61+13〓74
Henderson-Hasselbalch Equation Acid-base balance is mainly the balance between production and loss of acid and base. pH=pKa+lg[HCO3 －] [H2CO3 ] =pKa+lg20 1 = 6.1 +1.3 = 7.4
Acid-base balance pHa [HCO3]/[H2CO31 rpH∝[Hco]/Paco [H+]↑ Buffer Respiratory Renal pacO2 Excrete H+ ECF icF bone Keep nahco Neutralize eH+ &ik+ exchange H (Immediately)( 2-4h) (1~3min)(hs;1~3d)
[H+]↑ Buffer Respiratory Renal ECF ICF & bone (Immediately) ( 2~4h) (1~3min) (hs;1~3d) Neutralize H+ paCO2 ↓ eH+ & iK+ exchange Excrete H+ Keep NaHCO3 Acid-base balance ： pH∝ [HCO3 －] / [H2CO3 ] or pH∝ [HCO3 －] / PaCO2
细胞外液 Buffer H 饮食 ystem 1.0mmol H/(kg HCO3/H2CO H2oSO4.HPO2有机酸) Source 新形成 C02 HCO3 HPO4 /H2P04 Prot"/HP 代谢 13000-15000 H mmol CO2/d HCO R ena Respiratory CI K 细胞成分 04 HPOA/H2 POA 1. 0mmal H/ gd) H5 /HHb 排泄 HbO2/HHbO2 H20 13000~15000 HCO3/H2C0 mmol Co,/d Cellular 中枢神经调节 PTH 调节 图4-1酸碱的生成、缓冲与调节
Source Buffer system Renal Respiratory Cellular
(I) blood buffer system Buffer systems: consists of a weak acid and its,salt XXHCO3/H2 C03 is the most important buffer pair. 表1全血五种缓冲系统表2全血中各缓冲体系的含量与分布 缓冲酸缓冲碱 缓冲体系 占全血缓冲体系% H2CO3 HCO2 H+ 血浆HcO3 35 H2PO4 HPO42 H+ 红细胞内Hb 18 HPr Pr +H+ Hbo2及Hb 35 HHb Hb +H+ 磷酸盐 5 HBo HbO2 H 血浆蛋白
（I）blood buffer system 表1 全血五种缓冲系统 表2 全血中各缓冲体系的含量与分布 缓冲酸 缓冲碱 缓冲体系 占全血缓冲体系% H2CO3 HCO3 ¯ + H+ 血浆HCO3 ¯ 35 H2PO4 - HPO4 2 ¯+ H+ 红细胞内Hb 18 HPr Pr ¯ + H+ HbO2 -及Hb- 35 HHb Hb¯ + H+ 磷酸盐 5 HHbO2 HbO2¯ + H+ 血浆蛋白 7 Buffer systems ：consists of a weak acid and its’ salt ※HCO3 - /H2CO3 is the most important buffer pair
HCO3/H2CO3 buffer system Regulate co, or Hco, through kidney and lung, the most important buffer pair(50%o) fixed acid and base buffer system &PH is dermatied by HCO3 /H2CO3o
❖Regulate CO2 or HCO3 - through kidney and lung， the most important buffer pair (50%)。 ❖fixed acid and base buffer system HCO3 - /H2CO3 buffer system ❖PH is dermatied by HCO3 - /H2CO3