I Sources of acid and base The main origin of acid and base is the intracellular metabolism (catabolism of protein, carbohydrate and fat) (D Source of acid volatile acid fixed acid
(I) Source of acid ❖ volatile acid ❖ fixed acid II、Sources of acid and base The main origin of acid and base is the intracellular metabolism (catabolism of protein, carbohydrate and fat)
☆1 volatile acid-—H2CO3 metabolism of protein, carbohydrate and fat co+O、HCO3→H+HCo3 CA daily production 300-40QL/d Reabsorption in kidney Excretion: lung RBC、 kidney tubulesepithelium, alveolar pithelial cell, gastric mucosa
daily production ：300-400L/d Excretion:lung ❖ 1.volatile acid—— H2CO3 CO2 ＋ H2O H2CO3 CA metabolism of protein, carbohydrate and fat H+ + HCO3 - Reabsorption in kidney RBC、kidney tubulesepithelium 、alveolar epithelial cell 、gastric mucosa
2. unvolatile acid(fixed acid): (50-100mmol/d) Uric acid, phosphoric acid(H3PO4)and sulfuric acid (H2S04)are the products in the metabolic process of proteins and nuclear acids Lactic acid and ketonic bodies(B-hydroxybutyric acid and acetoacetic acid) can be formed from the metabolic process of carbohydrate and fat as intermediate proaucts, when the oxygen supply is not sufficiency Exogenous acid( food and drug s Excretion through kidney
2. unvolatile acid (fixed acid) ： (50-100mmol/d) Uric acid, phosphoric acid (H3PO4) and sulfuric acid (H2SO4) are the products in the metabolic process of proteins and nuclear acids. Lactic acid and ketonic bodies (β-hydroxybutyric acid and acetoacetic acid) can be formed from the metabolic process of carbohydrate and fat as intermediate products, when the oxygen supply is not sufficiency. Exogenous acid(food and drug)： Excretion through kidney
(D) Sources of base e Origin of bases ● Endogenous: deamination ->NH3 Less than acid production o Exogenous input: vegetables, and fruits
(II) Sources of base Origin of bases ⚫ Endogenous： deamination―>NH3 Less than acid production ⚫ Exogenous input： vegetables, and fruits
I Regulation of acid-base balance
III、 Regulation of acid-base balance