求子 Shandong universit Chapter 4 Acid-base balance and acid-base disorders Department of Pathophysiology, the School of Medicine, Shandong University 薛冰
Chapter 4 Acid-base balance and acid-base disorders Department of Pathophysiology, the School of Medicine, Shandong University 薛冰
internal environment homeostasis Water balance /homeostasis acid-base balance electrolyte balance
internal environment homeostasis Water balance homeostasis acid-base balance electrolyte balance
Contents 1. Acid-Base Balance Acid-base biochemistry Regulation of pl H Laboratory tests 02. Simple acid-base disorders e Metabolic Acidosis e Respiratory acidosis o Metabolic Alkalosis Respiratory alkalosis e3. Mixed Acid-base Disturbance
1. Acid-Base Balance ⚫ Acid-base Biochemistry ⚫ Regulation of pH ⚫ Laboratory Tests 2. Simple Acid-base Disorders ⚫ Metabolic Acidosis ⚫ Respiratory Acidosis ⚫ Metabolic Alkalosis ⚫ Respiratory Alkalosis 3. Mixed Acid-base Disturbance Contents
Part l: Acid-base balance and its regulation The basic meaning of acid-base balance is the stable H+ in the body fluid
Part I: Acid-base balance and its regulation ⚫The basic meaning of acid-base balance is the stable [H+] in the body fluid
I Concept of acid and base acid: An acid is a h+ donor when it is dissolved in water After the loss of ht. it becomes a base HA(acd)→H+A(base) H2CO3→H++HcO3 H2sO4, H3 PO4 base: a base is a H+ acceptor, when it is dissolved in water. After the combining of H+,it becomes an acid ●A(ase)+H+→HA(acid) HCO3+H+→H2Co3 OH, HCO3, SO42, HPO42, NH
I、Concept of acid and base acid ： An acid is a H+ donor, when it is dissolved in water. After the loss of H+ , it becomes a base. HA (acid) → H+ + Aˉ(base) H2CO3 → H+ +HCO3ˉ H2SO4 , H3PO4 base： A base is a H+ acceptor, when it is dissolved in water. After the combining of H+ , it becomes an acid Aˉ(base)+ H+ → HA (acid) HCO3ˉ +H+ → H2CO3 OH- , HCO3 - , SO4 2- , HPO4 2- , NH3