Antigen presenting cells and antigen presentation
Antigen presenting cells and antigen presentation
T cells do not recognise native antigens B R《 BCR交联 活化增殖、产生抗体 T T 无增殖 无CK产生
T cells do not recognise native antigens Y B Y Y Y Y Y Y Y B Y T Y T 活化增殖、产生抗体 无增殖 无CK产生 BCR交联 Y B Y B Y B Y B Y B Y B Y B
Processing and presentation of antigens APC (antigen presenting cells a. Processing and presenting pathway
Processing and presentation of antigens ◼ I. APC (antigen presenting cells) ◼ II. Processing and presenting pathway
I Antigen presenting cells ■ Concepts Endogenous antigens: antigens produced within cells Exogenous antigens: antigens internalized by endocytosis Ag capturing---m---Endocytosis Phagocytosis Pinocytosis Receptor-mediated endocytosis Ag processing and Ag presentation ■APc
I. Antigen presenting cells ◼ Concepts Endogenous antigens: antigens produced within cells Exogenous antigens: antigens internalized by endocytosis Ag capturing-------Endocytosis Phagocytosis Pinocytosis Receptor-mediated endocytosis Ag processing and Ag presentation ◼ APC
Antigen presenting cells Concepts Endogenous antigens: antigens produced within cells Exogenous antigens: antigens internalized by endocytosis Ag capturing-------Endocytosis Phagocytosis Pinocytosis Receptor-mediated endocytosis Ag processing and Ag presentation a protein antigen be degraded into peptides by a sequence of events The degraded peptides associate with MHc molecules and the peptides-MHC molecule complexes are transported to the membrane, where they are displayed
I. Antigen presenting cells ◼ Concepts Endogenous antigens: antigens produced within cells Exogenous antigens: antigens internalized by endocytosis Ag capturing-------Endocytosis Phagocytosis Pinocytosis Receptor-mediated endocytosis Ag processing and Ag presentation A protein antigen be degraded into peptides by a sequence of events The degraded peptides associate with MHC molecules, and the peptides-MHC molecule complexes are transported to the membrane, where they are displayed