hemoglobin buffer system(Hb/HHb, HbO2 /HHbO2) character: RBC specificity volatile acid buffer CO 2 CO2+H,O CA H2CO3 CA CA: carbonic anhydras HX HCO HCO3 HO2N Hbo3 c Hb (RBC)
character: RBC specificity volatile acid buffer CO2 CA：carbonic anhydrase CO2+H2O CA H2CO3 CA H + HCO3 - Cl- (RBC) HCO3 - Cl HHO - 2 HbO2 - HHb Hb ← - hemoglobin buffer system (Hb- /HHb、HbO2 - /HHbO2 )
phosphate buffer system e HPO42/HPO4 character: play a role in cell and kidney
phosphate buffer system HPO42- /H2PO4- character: play a role in cell and kidney
protein butter system e Pr-/HPr Intracellular buffer
protein buffer system Pr－/HPr Intracellular buffer
Mechanism of buffer HcH+ NaHco→NacH+H2cO3→cO2+H2O Naoh hcoa>Nahcoa+ ho Accept H+ or release H+ decrease the change of pH
Mechanism of buffer HCl+NaHCO3→NaCl+H2CO3→CO2+H2O NaOH + H2CO3→NaHCO3 + H2O Accept H+ or release H+ ， decrease the change of pH
Character of Buffer ● Unvolatile acid: ●HcO3/H2Co3 system 72 of the buffer capacity o Opened regulation respiratory and renal e Volatile acid Hb/HHb、HbO2 .HHbC2
Character of Buffer Unvolatile acid： ⚫ HCO- 3/H2CO3 system: ⚫ ½ of the buffer capacity ⚫ Opened regulation: respiratory and renal Volatile acid ： ⚫ Hb- /HHb、HbO2 - /HHbO2