Lecture 17-18 Hyperthermia treatment for tumors
Lecture 17-18 Hyperthermia treatment for tumors
Hyperthermia treatment for tumors Tumor Microenvironment Microvasculature Stage of tumor: 1.Dormant(no vasculature) 2.Vascularization (inducer:vascular growth factors) 3.Growth and Metastasis(new tumors) 4.Suppression of new tumors(inhibitors from main tumor), Necrotic(less perfusion in tumor center (in animal at least) ->average perfusion decrease)
Hyperthermia treatment for tumors • Tumor Microenvironment & Microvasculature – Stage of tumor: 1. Dormant (no vasculature) 2. Vascularization (inducer: vascular growth factors) 3. Growth and Metastasis (new tumors) 4. Suppression of new tumors (inhibitors from main tumor), Necrotic (less perfusion in tumor center (in animal at least) ->average perfusion decrease)
I.E, w256 Carcinosarcoma in rats (R.K.Jain,1977) Wo=WoN i in necrotic zone =10 WoN i in viable zone Canine lymphosarcoma (Tuttle etal.1964;Straw etal, 1974 Wb=1.2+15.1(r/R)2ml/min/g
I.E. w256 Carcinosarcoma in rats (R.K. Jain, 1977) Wb= WbN in necrotic zone =10 WbN in viable zone Canine lymphosarcoma (Tuttle etal. 1964; Straw etal, 1974) Wb=1.2+15.1(r/R)2 ml/min/g
Therapeutic approaches: Anti-angiogenic drug (Dr.Moses.J.Folkman Boston Children's Hospital May,1998. Newa week Blood supply↓ Hyperthermia
Therapeutic approaches: Blood supply ↓ Anti-angiogenic drug (Dr. Moses.J.Folkman Boston Children’s Hospital May, 1998. Newa week Hyperthermia
Hyperthermia effect 1866(Busch):erysipelas (insect)attack >high fever->cure for a facial sarcoma 189i(coley小：bacterial toxins→high fever (cancer patients)>reduced cancer size 1900:experiments done in lab animals> thermal dose (elevated temp.,duration)> effective treatment
Hyperthermia effect 1866(Busch): erysipelas (insect) a Ʃack →high fever → cure for a facial sarcoma 1891(coley): bacterial toxins → high fever (cancer pa Ɵents) → reduced cancer size 1900: experiments done in lab animals → thermal dose (elevated temp., dura Ɵon) → effective treatment