1970s&1980s: Exp.studies at the cellular level> tumor cells are more sensitive to heat than normal cells due to abnormal molar ratios of cholesterol phospholipid Elevated temperature at 43C for a period of time is more lethal to tumor cells. cholesterol phospholipid↑→heat resistance of cells↑
1970s&1980s: Exp. studies at the cellular level → • tumor cells are more sensitive to heat than normal cells due to abnormal molar ratios of cholesterol phospholipid – Elevated temperature at 43℃ for a period of time is more lethal to tumor cells. cholesterol phospholipid↑ → heat resistance of cells ↑
1980s-present Numerous Exp Clinical trials Hyperthermia alone->partial reduction of tumor size Hyperthermia w/ionized(reduced hypoxia)radiation therapy -better results Hyperthermia (increased circulation,increased vascular wall permeability to drugs)->better results
1980s-present – Numerous Exp & Clinical trials – Hyperthermia alone->partial reduction of tumor size – Hyperthermia w/ ionized (reduced hypoxia) radiation therapy -> better results – Hyperthermia (increased circulation, increased vascular wall permeability to drugs) -> better results
Effective Hyperthermia treatment a.Heating source selection: Surface Heating (local or whole body)-"Boundary condition" Hot water bath or moist air incubator Space suit and blanket techniques ● Infrared radiation Hot wax bath(molten paraffin wax having melting point of46℃) Regional systemic perfusion with heated blood Implantation of a heat source and electrocoagulation
Effective Hyperthermia treatment a. Heating source selection: Surface Heating (local or whole body)-”Boundary condition” • Hot water bath or moist air incubator • Space suit and blanket techniques • Infrared radiation • Hot wax bath (molten paraffin wax having melting point of 46 ℃ ) • Regional & systemic perfusion with heated blood • Implantation of a heat source and electrocoagulation