Dynamic Vascular Response a)Structure Nerve of blood vessel Vata tasortm Adventitia External elastic lamina Tunica media Internal elastic lamina T'umica intima Endothelitom o可 【,a Lumen Lymphatic Ue结e Variable basal C打dothelum
a) Structure Dynamic Vascular Response
Passive Mechanical Wall Composition (Wall Elasticity, Systemic, Endothelium,Elastic, Compliance) Pressure Muscle,Nerves Fibrous Vessel Lumen Size Nerve Vasoactive Substances Active Center Nerve,Hormous,Endothelium External Stimuli
Vasoactive Substances Nerve, Hormous, Endothelium Wall Composition Endothelium, Elastic, Muscle, Nerves Fibrous Vessel Lumen Size Systemic Pressure Nerve Center Passive Mechanical (Wall Elasticity, Compliance) External Stimuli Active
b)Contractile apparatus -Smooth muscle cell: 。Spindle shaped 。Center diameter::3-8μm,length:15um-200μm
b) Contractile apparatus – Smooth muscle cell: • Spindle shaped • Center diameter:3‐8μm, length: 15 μm‐200μm
Two types of filaments: Thin filaments of cytoplasmic actin ·myosin Intermediate filament Thick filament (Myosin) Thin filament (Actin) Dense body
• Two types of filaments: • Thin filaments of cytoplasmic actin • myosin
Ca2+ Calmodulin Ca2+-calmodulin Inactive myosin kinase Active myosin kinase ATP- ADP Inactive myosin Phosphorylated myosin 2001 BrockuCole-Thomson Leaming (can bind with actin) Release of Bind Ca2+into calmodulin(protein) the muscle cell Activate myosin Contraction
Release of Ca2+ into the muscle cell Bind calmodulin(protein) Activate myosin Contraction